Cancer cachexia is characterized by metabolic dysregulation, inflammation, and reduced food intake, and it results in loss of skeletal muscle. Although cachexia is pervasive in patients with advanced cancer, comprehensive cachexia care is inadequate because of a lack of screening and awareness of the impact cachexia has on oncology care, including anticancer treatments, functional status, and psychosocial distress. Oncology nurses at all levels of practice need to screen for cachexia, educate patients about cachexia, monitor symptoms, facilitate interprofessional interventions, and provide psychosocial support to improve treatment outcomes and quality of life for patients with cachexia.