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Biotherapy

Online Exclusive Article

Biosimilars: Considerations for Oncology Nurses

Vida Vizgirda
Ira Jacobs
CJON 2017, 21(2), E54-E60 DOI: 10.1188/17.CJON.E54-E60
Background: Biosimilars are developed to be highly similar to and treat the same conditions as licensed biologics. As they are approved and their use becomes more widespread, oncology nurses should be aware of their development and unique considerations. Objectives: This article reviews properties...
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Safety

Minimizing Hazards Associated With Live-Virus Immunotherapeutic Cancer Vaccines

Sheri McMahon
CJON 2016, 20(6), 602-604 DOI: 10.1188/16.CJON.602-604
Therapeutic cancer vaccines that use attenuated vaccinia viruses as delivery vectors are undergoing clinical trials at dozens of sites internationally. Even in an attenuated form, these live viruses can cause severe illness if they are accidentally transmitted to immunocompromised people, pregnant...
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Clinical Challenges

The Evolving Context of Driver Mutations: ROS1 Rearrangement in Metastatic Non-Small Cell Lung Cancer

Ximena DeCaire
Erin Streu
ONF 2016, 43(5), 544-547 DOI: 10.1188/16.ONF.544-547
The discovery of driver mutations in non-small cell lung cancer (NSCLC) has led to the advent of targeted therapy and changed the clinical landscape. ROS1 is a rare driver mutation found in 1%–2% of patients diagnosed with NSCLC. This case highlights a young woman of Asian descent with no history...
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CJON Writing Mentorship Article

Update on New Therapies With Immune Checkpoint Inhibitors

Jennifer J. Peterson
Susan K. Steele-Moses
CJON 2016, 20(4), 405-410 DOI: 10.1188/16.CJON.405-410
Background: Immunotherapy has had a long history in cancer treatment and, with recent breakthroughs, new drugs are available that have shown promising results. Objectives: The current article discusses an overview of immune function, including immunoediting and the theory of immune checkpoints, as...
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Advanced Practice Nursing Issues

Subcutaneous Immunoglobulin in Oncology Clinical Practice

Erin Streu
CJON 2016, 20(4), 437-439 DOI: 10.1188/16.CJON.437-439
The administration of gammaglobulin as replacement therapy to boost immune function in patients with immunodeficiency secondary to malignancy is traditionally given in the IV formulation. A pilot program at a large Canadian cancer center led by an advanced practice nurse (APN) demonstrated that...
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