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Palliative Care and Phase 1 Trials: Intervention to Improve Quality of Life and Provide Education

Betty R. Ferrell
Vincent Chung
Marianna Koczywas
Anna Cathy Williams
Denise Gallagher
Patricia Fischer
Thomas J. Smith
CJON 2017, 21(4), 473-479 DOI: 10.1188/17.CJON.473-479
Background: Patients in phase 1 clinical trials often have significant symptom burdens and quality-of-life concerns that increase as they progress along the cancer trajectory and experience drug toxicities from the clinical trial. Objectives: The interdisciplinary intervention described is aimed at...
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CAR T-Cell Therapy Effects: Review of Procedures and Patient Education

Holly McConville
Megan Harvey
Colleen Callahan
Laura Motley
Heather Difilippo
Claire White
CJON 2017, 21(3), DOI: 10.1188/17.CJON.E79-E86
Background: Chimeric antigen receptor (CAR) T-cell therapy is a cellular immunotherapy that redirects the killing activity of T cells to fight tumor cells. CD19 CAR T-cell therapies have demonstrated high rates of complete response in clinical trials in patients with relapsed or refractory B-cell...
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Oncolytic Viruses: Treatment and Implications for Patients With Gliomas

Cheryl Martin
CJON 2017, 21(2), 60-64 DOI: 10.1188/17.CJON.S2.60-64
Background: Oncolytic viral therapies are increasingly being explored for the treatment of diverse cancer types, most notably melanoma. However, advances in the treatment of high-grade gliomas, and specifically glioblastoma multiforme (GBM), are the result of novel oncolytic viral therapies. Delta-...
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Article

Immunotherapy: Exploring the State of the Science

Pamela K. Ginex
Kelly Brassil
Beth Ely
CJON 2017, 21(2), 9-12 DOI: 10.1188/17.CJON.S2.9-12
Immunotherapy research provides opportunities for nurse scientists and researchers to be at the forefront of the changing landscape of cancer treatment. As these therapies continue to develop, current initiatives will seek to support nurses in clinical practice who must provide safe, evidence-based...
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Clinical Moment

How Can I Change My Patients’ Treatment Decision Making by Becoming a Nurse Scientist?

Tamryn F. Gray
CJON 2017, 21(2), 263 DOI: 10.1188/17.CJON.263
“What would you do?” I have heard this question numerous times throughout my nursing career by patients and families affected by cancer. As a pediatric blood and marrow transplantation nurse, I have often seen patients and their families wrestle with difficult treatment decisions. I have witnessed...
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