Zoledronic acid inhibits the resorption of mineralized bone and cartilage. It inhibits the increased osteoclastic activity and skeletal calcium that is induced by stimulatory factors released by malignant tumors. Zoledronic acid is indicated for the treatment of hypercalcemia, multiple myeloma, and...

Epirubicin is a semisynthetic derivative of daunorubicin and the 4'-epimer of doxorubicin. Its action is unclear; it forms a complex with DNA, causing inhibition of nucleic acid and protein synthesis. The drug appears to interfere with replication and transcription of DNA, leading to cell death.

Hepatocellular carcinoma (HCC) is a common malignancy worldwide and is a disease of multifactorial etiology. Strong correlations exist between the prevalence of the hepatitis B and C viruses and HCC incidence. HCC treatment may involve surgical resection, liver transplantation, locoregional...

Imatinib mesylate is indicated in the treatment of patients with chronic myeloid leukemia (CML) in blast crisis, the accelerated phase of disease, or in the chronic phase of disease after not responding to interferon-alpha therapy. Studies are being conducted to evaluate the drug in treating...