Since the early 2000s, significant discussion about evidence-based practice (EBP) has occurred in the healthcare arena and early steps have been taken toward it; however, searching the EBP literature can be overwhelming. A MEDLINE® (EBSCO) search for evidence-based practice yielded interesting results. When limited to 1999 or prior, 635 articles were identified starting at 1987, and when limited to 2000-2013, 11,511 articles were identified, an 18-fold increase. The concept of EBP has been readily adopted in the healthcare community. However, the questions that remain are: So what? Who cares? Has this avalanche of new information truly changed practice or just added more layers to practice and workloads? Where do we go next? The focus of the current article is to present current initiatives directed toward integrating research and clinical knowledge through interdisciplinary and transdisciplinary processes.