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Journal Club

Androgen-Deprivation Therapy and Metabolic Syndrome in Men With Prostate Cancer

Joanne M. Harrington
Dawn C. Schwenke
Dana R. Epstein
Donald E. Bailey
ONF 2014, 41(1), 21-29 DOI: 10.1188/14.ONF.21-29

Purpose/Objectives: To examine the trajectory of changes in body composition and metabolic profile in men who receive androgen-deprivation therapy (ADT) for prostate cancer.

Design: Prospective longitudinal design with repeated measures.

Setting: Urban medical center in the southwestern United States.

Sample: 55 men starting radiation therapy for prostate cancer.

Methods: Changes in the parameters of metabolic syndrome were estimated with ADT (n = 31) and non-ADT (n = 24) groups by repeated-measures analysis of variance implemented by general linear mixed-effects models. Models included interactions between groups and follow-up time to test differences between the groups.

Main Research Variables: Body composition and metabolic variables.

Findings: The ADT group demonstrated a transient increase in waist circumference at the nine-month time point and significant changes in measures of insulin resistance were noted at the three month point. Values for diastolic and systolic blood pressure, plasma glucose, high-density lipoprotein, and triglycerides were not altered for either group. Differences in metabolic variables or measures of body composition did not differ significantly between the groups.

Conclusions: The findings demonstrate the development of insulin resistance in men receiving ADT as early as three months after starting ADT.

Implications for Nursing: Addressing survivorship concerns can lead to the development of nursing interventions designed to reduce adverse effects associated with ADT.