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Symptom Clusters in Patients With Pancreatic Cancer Undergoing Surgical Resection: Part II

Sherry A. Burrell
Theresa P. Yeo
Suzanne C. Smeltzer
Benjamin E. Leiby
Harish Lavu
Eugene P. Kennedy
Charles J. Yeo
ONF 2018, 45(4), E53-E66 DOI: 10.1188/18.ONF.E53-E66

Objectives: To explore the relationship between 16 symptom clusters (SCs), clinical and demographic influencing factors, and clinical outcomes over time in patients with pancreatic cancer (PC) undergoing surgical resection.

Sample & Setting: 143 patients with stage II PC undergoing surgical resection were recruited to participate in this longitudinal, exploratory study conducted at Thomas Jefferson University Hospital, a National Cancer Institute–designated cancer center.

Methods & Variables: Quality of life was measured preoperatively and at three, six, and nine months postoperatively. Statistical methods included simple linear and Cox proportional hazard regression.

Results: Preoperative pain was significantly associated with the pain–gastrointestinal SC, and preoperative worry was significantly associated with the mood SC. The strongest negative association with emotional well-being across all study time points was found with the preoperative mood SC. The insomnia–digestive problems SC and the nutritional problems SC demonstrated a trend toward poor survival.

Implications for Nursing: Findings provide evidence that preoperative worry and pain are associated with SC severity and that SCs may have a detrimental effect on quality of life and survival in patients with PC undergoing surgical resection.

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