Presumed Glioblastoma Multiforme: A Case for Biopsy Prior to Treatment

Glioblastoma multiforme (GBM) is the most lethal and aggressive primary brain tumor. Several other abnormalities (neoplastic, infectious, or vascular) can mimic symptoms seen with GBM. This article reviews GBM and presents a case study that demonstrates the rationale for biopsy and pathologic diagnosis prior to the initiation of treatment for malignant brain tumors.

At a Glance

• Many conditions present as clinical mimics of glioblastoma multiforme.
• Surgical intervention allows for biopsy, which permits accurate clinical diagnosis and possible debulking of tumor mass.
• Pathologic diagnosis enables safe and effective treatment decisions and planning.