Alexandrescu, D.T., Vaillant, J.G., & Dasanu, C.A. (2006). Effect of treatment with a colloidal oatmeal lotion on the acneform eruption induced by epidermal growth factor receptor and multiple tyrosine-kinase inhibitors. Clinical and Experimental Dermatology, 32, 71–74.

To evaluate the effectiveness of colloidal oatmeal lotion (Aveeno^®), administered TID for at least seven days.

• The study reported on a sample of 10 patients.
• Patients were receiving epidermal growth factor receptor–inhibitor (EGFRI) and tyrosine-kinase inhibitor (TKI) therapy (e.g., cetuximab, erlotinib, panitumumab, sorafenib) and were experiencing cutaneous reactions.

Multiple centers in Washington, DC, and New York, NY

This was an open-label study used to evaluate the rate and quality of response to colloidal oatmeal lotion.

Toxicity was graded as follows.

• Grade 1: asymptomatic, erythematous rash
• Grade 2: rash plus itching
• Grade 3: confluent lesions and tenderness
• Grade 4: deep ulcerations and exfoliative or severe xerosis

• Ten of 11 patients were evaluable.
• Six patients had a complete response and four had a partial response; therefore, the response rate was 100%.
• Responses occurred from six to 10 days after initiation of colloidal oatmeal lotion.

Treatment with colloidal oatmeal lotion appeared to be effective in controlling rash associated with EGFRIs and multiple TKIs. This treatment allowed for the continuation of antineoplastic therapy.

• This was a small, nonrandomized, open-label study.
• The description of the measurement tool or method used to grade rash symptoms was inadequate; reliability and validity were unclear.