Amar, D., Grant, F.M., Zhang, H., Boland, P.J., Leung, D.H., & Healey, J.A. (2003). Antifibrinolytic therapy and perioperative blood loss in cancer patients undergoing major orthopedic surgery. Anesthesiology, 98, 337–342.
 

DOI Link

Study Purpose

To determine if e amino-caproic acid (EACA) will reduce perioperative blood loss in patients with cancer undergoing orthopedic surgery (intraoperative plus 48 hours)

Sample Characteristics

  • N = 69
  • OTHER KEY SAMPLE CHARACTERISTICS: Undergoing major orthopedic surgery

Setting

  • LOCATION: Memorial Sloan-Kettering Cancer Center

Study Design

  • Randomized, double-blind, placebo-controlled trial of IV aprotinin, EACA, or saline placebo

Measurement Instruments/Methods

  • D-dimer levels, red blood cells (RBCs) transfused, and bleeding, which was defined as hemoglobin, hematocrit, platelet count, prothrombin time, PPT
  • Measurements occurred at three times: preoperative, postanesthesia care unit, and postoperative on day two
     

Results

Blood loss and RBC units transfused did not differ. The two treated groups had a significantly lower D-dimer level (P < 0.01).

Limitations

  • Sample size
  • Power insufficient, especially with three arms