Buchsel, P.C., & Murphy, P.J.M. (2008). Polyvinylpyrrolidone-sodium hyaluronate gel (Gelclair®): a bioadherent oral gel for the treatment of oral mucositis and other painful oral lesions. Expert Opinion on Drug Metabolism and Toxicology, 4, 1449-1454.
DOI Link
Purpose & Patient Population
PURPOSE: Review the benefit of polyvinylpyrrolidone-sodium hyaluronate gel (Gelclair) for oral mucositis
Type of Resource/Evidence-Based Process
RESOURCE TYPE: Expert opinion
Phase of Care and Clinical Applications
PHASE OF CARE: Active treatment
Results Provided in the Reference
Various uses and mechanism of action of hyaluronic gel (Gelclair) are discussed. Six studies/articles are summarized. Only one article provided any significant findings. One other article related to oral mucositis was a case study. The author suggests that Gelclair may be a useful additional therapy to help with pain caused by oral lesions. It may contribute to improved drinking, eating, and swallowing, and may improve nutritional status and quality of life.
Guidelines & Recommendations
May be effective for pain related to mucositis
Nursing Implications
A large control trial is needed to increase the strength of recommending Gelclair. Evidence provided here is weak and very limited regarding examination of Gelclair for oral mucositis in patients with cancer.