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Herbs or Natural Products That Protect Against Cancer Growth: Part Three of a Four-Part Series

Muriel J. Montbriand
ONF 2004, 31(6), E127-E146 DOI: 10.1188/04.ONF.E127-E146

Purpose/Objectives: To provide evidence-based research information about 47 herbs and natural products that have the potential to protect against the development of cancer.


Agarwal, K.C., & Parks, R.E. (1983). Forskolin: A potential antimetastatic agent. <i>International Journal of Cancer, 32</i>, 801-804.

Ahn, Y.O. (1997). Diet and stomach cancer in Korea. <i>International Journal of Cancer, 10</i>(Suppl.), 7-9.

Alabaster, O., Tang, Z.C., Frost, A., & Shivapurkar, N. (1993). Potential synergism between wheat bran and psyllium: Enhanced inhibition of colon cancer. <i>Cancer Letters, 75</i>, 53-58.

Albright, C.D., Liu, R., Mar, M.H., Shin, O.H., Vrablic, A.S., Salganik, R.I., et al. (1997). Diet, apoptosis, and carcinogenesis. <i>Advances in Experimental Medicine and Biology, 422</i>, 97-107.

Alic, M. (1999). Green tea for remission maintenance in Crohn's disease. <i>American Journal of Gastroenterology, 94</i>, 1710-1711.

American Cancer Society 1996 Advisory Committee on Diet, Nutrition, and Cancer Prevention. (1996). Guidelines on diet, nutrition, and cancer prevention: Reducing the risk of cancer with healthy food choices and physical activity. <i>CA: A Cancer Journal for Clinicians, 46</i>, 325-341.

Anesini, C., Ferraro, G., Lopez, P., & Borda, E. (2001). Different intracellular signals coupled to the antiproliferative action of aqueous crude extract from Larrea divaricata Cav. and nor-dihydroguaiaretic acid on a lymphoma cell line. <i>Phytomedicine, 8</i>(1), 1-7.

Ascherio, A., Rimm, E.B., Giovannucci, E.L., Spiegelman, D., Stampfer, M., & Willett, W.C. (1996). Dietary fat and risk of coronary heart disease in men: Cohort follow up study in the United States. <i>BMJ, 313</i>, 84-90.

Ashar, B., & Vargo, E. (1996). Shark cartilage-induced hepatitis. <i>Annals of Internal Medicine, 125</i>, 780-781.

Auer, W., Eiber, A., Hertkorn, E., Hoehfeld, E., Koehrle, U., Lorenz, A., et al. (1990). Hypertension and hyperlipidaemia: Garlic helps in mild cases. <i>British Journal of Clinical Practice Supplement, 69</i>, 3-6.

Awad, A.B., Chen, Y.C., Fink, C.S., & Hennessey, T. (1996). Beta-sitosterol inhibits HT-29 human colon cancer cell growth and alters membrane lipids. <i>Anticancer Research, 16</i>, 2797-2804.

Awad, A.B., von Holtz, R.L., Cone, J.P., Fink, C.S., & Chen, Y.C. (1998). Beta-sitosterol inhibits growth of HT-29 human colon cancer cells by activating the sphingomyelin cycle. <i>Anticancer Research, 18</i>, 471-473.

Badary, O.A., Al-Shabanah, O.A., Nagi, M.N., Al-Rikabi, A.C., & Elmazar, M.M. (1999). Inhibition of benzo(a)pyrene-induced forestomach carcinogenesis in mice by thymoquinone. <i>European Journal of Cancer Prevention, 8</i>, 435-440.

Bagui, S., Ray, M., & Ray, S. (1999). Glyceraldehyde-3-phosphate dehydrogenase from Ehrlich ascites carcinoma cells. <i>European Journal of Biochemistry, 262</i>, 386-395.

Bailey, G.S., Dashwood, R.H., Fong, A.T., Williams, D.E., Scanlan, R.A., & Hendricks, J.D. (1991). Modulation of mycotoxin and nitrosamine carcinogenesis by indole-3-carbinol: Quantitative analysis of inhibition versus promotion. <i>IARC Scientific Publications, 105</i>, 275-280.

Batchelor, W.B., Heathcote, J., & Wanless, I.R. (1995). Chaparral-induced hepatic injury. <i>American Journal of Gastroenterology, 90</i>, 831-833.

Bell, M.C., Crowley-Nowick, P., Bradlow, H.L., Sepkovic, D.W., Schmidt-Grimminger, D., Howell, P., et al. (2000). Placebo-controlled trial of indole-3-carbinol in the treatment of CIN. <i>Gynecologic Oncology, 78</i>, 123-129.

Berges, R.R., Windeler, J., Trampisch, H.J., & Senge, T. (1995). Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. <i>Lancet, 345</i>, 1529-1532.

Bisset, N.G., & Wichtl, E. (Eds.). (1994). <i>Herbal drugs and phytopharmaceuticals. A handbook for practice on a scientific basis.</i> London: Medpharm.

Blankson, H., Stakkestad, J.A., Fagertun, H., Thom, E., Wadstein, J., & Gudmundsen, O. (2000). Conjugated linoleic acid reduces body fat mass in overweight and obese humans. <i>Journal of Nutrition, 130</i>, 2943-2948.

Bleumink, E., Mitchell, J.C., Geismann, T.A., & Towers, G.H. (1976). Contact hypersensitivity to sesquitepene lactones in chrysanthemum dermatitis. <i>Contact Dermatitis, 2</i>, 81-88.

Bloch, A.S. (2000). Pushing the envelope of nutrition support: Complementary therapies. <i>Nutrition, 16</i>, 236-239.

Bluhm, R., Branch, R., Johnston, P., & Stein, R. (1990). Aplastic anemia associated with canthaxanthin ingested for ‘tanning’ purposes. <i>JAMA, 264</i>, 1141-1142.

Blumenthal, M., Busse, W.R., Goldberg, A., Gruenwald, J., Hall, T., Riggins, C.W., et al. (Eds.). (1998). <i>The complete German commission E monographs: Therapeutic guide to herbal medicines</i> (S. Klein, Trans.). Boston: American Botanical Council.

Bomser, J., Madhavi, D.L., Singletar, K., & Smith, M.A. (1996). In vitro anticancer activity of fruit extracts from Vaccinium species. <i>Planta Medica, 62</i>, 212-216.

Bouhnik, Y., Pochart, P., Marteau, P., Arlet, G., Goderel, I., & Rambaud, J.C. (1992). Fecal recovery in humans of viable bifidobacterium ingested in fermented milk. <i>Gastroenterology, 102</i>, 875-878.

Bounous, G., Batist, G., & Gold, P. (1991). Whey proteins in cancer prevention. <i>Cancer Letters, 57</i>, 91-94.

Bradlow, H.L., Michnovicz, J., Telang, N.T., & Osborne, M.P. (1991). Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice. <i>Carcinogenesis, 12</i>, 1571-1574.

Brinker, F. (1998). <i>Herb contraindications and drug interactions</i> (2nd ed.). Sandy, OR: Eclectic Medical.

Brown, G.A., Vukovich, M.D., Reifenrath, T.A., Uhl, N.L., Parsons, K.A., Sharp, R.L., et al. (2000). Effects of anabolic precursors on serum testosterone concentration and adaptions to resistance training in young men. <i>International Journal of Sport Nutrition and Exercise Metabolism, 10</i>, 340-359.

Butland, B.K., Fehily, A.M., & Elwood, P.C. (2000). Diet, lung function, and lung function decline in a cohort of 2512 middle aged men. <i>Thorax, 55</i>, 102-108.

Cao, Y., & Cao, R. (1999). Angiogenesis inhibited by drinking tea [Letter to the editor]. <i>Nature, 398</i>, 381.

Chasan-Taber, L., Willett, W.C., Seddon, J.M., Stampfer, M.J., Rosner, B., Colditz, G.A., et al. (1999). A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in U.S. women. <i>American Journal of Clinical Nutrition, 70</i>, 509-526.

Chew, B.P., Park, J.S., Wong, M.W., & Tong, T.S. (1999). A comparison of the anticancer activities of dietary beta-carotene, canthaxanthin and astaxanthin in mice in vivo. <i>Anticancer Research, 19</i>, 1849-1854.

Chew, B.P., Wong, M.W., Park, J.S., & Wong, T.S. (1999). Dietary beta-carotene and astaxanthin but not canthaxanthin stimulate splenocyte function in mice. <i>Anticancer Research, 19</i>, 5223-5228.

Christensen, J.H., Christensen, M.S., Toft, E., Dyerberg, J., & Schmidt, E.B. (2000). Alpha-linolenic acid and heart rate variability. <i>Nutrition, Metabolism, and Cardiovascular Diseases, 10</i>, 57-61.

Circosta, C., Occhiuto, F., Ragusa, S., Trovato, A., Tumino, G., Briguglio, F., et al. (1984). A drug used in traditional medicine: Harpagophytum procumbens DC. II. Cardiovascular activity. <i>Journal of Ethnopharmacology, 11</i>, 259-274.

Clinton, S.K., Emenhiser, C., Schwartz, S.J., Bostwick, D.G., Williams, A.W., Moore, B.J., et al. (1996). Cis-trans lycopene isomers, carotenoids, and retinol in the human prostate. <i>Cancer Epidemiology, Biomarkers and Prevention, 5</i>, 823-833.

Colditz, G.A. (2000). Changing dietary patterns and cancer prevention: Alpha-linolenic acid health risks and benefits. <i>Cancer Causes and Control, 11</i>, 677-678.

Consensus statement on cereals, fibre and colorectal and breast cancers. Proceeding of the European Cancer Prevention consensus meeting. Santa Margheritia, Italy, 2-5 October 1997. (1998). <i>European Journal of Cancer Prevention, 7</i>(Suppl. 2), S1-S83.

Covington, T.R. (Ed.). (1996). <i>Handbook of nonprescription drugs</i> (11th ed.). Washington, DC: American Pharmaceutical Association.

Dashwood, R.H. (1998). Indole-3-carbinol: Anticarcinogen or tumor promoter in brassica vegetables? <i>Chemico-Biological Interactions, 110</i>(1-2), 1-5.

de Jong, N.W., Vermeulen, A.M., van Wijk, R.G., & de Groot, H. (1998). Occupational allergy caused by flowers. <i>Allergy, 53</i>, 204-209.

De Stefani, E., Deneo-Pellegrini, H., Boffetta, P., Ronco, A., & Mendilaharsu, M. (2000). Alpha-linolenic acid and risk of prostate cancer: A case-control study in Uruguay. <i>Cancer Epidemiology, Biomarkers and Prevention, 9</i>, 335-338.

Duke, J.A. (1987). <i>CRC handbook of medicinal herbs.</i> Boca Raton, FL: CRC Press.

Duke, J.A. (1997). <i>The green pharmacy.</i> Emmaus, PA: Rodale Press.

Efendy, J.L., Simmons, D.L., Campbell, G.R., & Campbell, J.H. (1997). The effect of the aged garlic extract ‘Kyolic,’ on the development of experimental atherosclerosis. <i>Atherosclerosis, 132</i>(1), 37-42.

Eigenmann, P.A., Burks, A.W., Bannon, G.A., & Sampson, H.A. (1996). Identification of unique peanut and soy allergens in sera adsorbed with cross-reacting antibodies. <i>Journal of Allergy and Clinical Immunology, 98</i>, 969-978.

Eisenberg, D.M., Davis, R.B., Ettner, S.L., Appel, S., Wilkey, S., Van Rompay, M., et al. (1998). Trends in alternative medicine in the United States, 1990-1997. <i>JAMA, 280</i>, 1569-1575.

Eisenberg, D.M., Kessler, R.C., Foster, C., Norlock, F.E., Calkins, D.R., & Delbanco, T.L. (1993). Unconventional medicine in the United States: Prevalence, cost and patterns of use. <i>New England Journal of Medicine, 328</i>, 246-252.

El Attar, T.M., & Virji, A.S. (1999). Modulating effect of resveratrol and quercetin on oral cancer cell growth and proliferation. <i>Anticancer Drugs, 10</i>, 187-193.

Ernst, E. (2000a). Prevalence of use of complementary/alternative medicine: A systematic review. <i>Bulletin of the World Health Organization, 78</i>, 252-257.

Ernst, E. (2000b). The role of complementary and alternative medicine in cancer. <i>Lancet Oncology, 1</i>(3), 176-180.

Ernst, E., & Cassileth, B.R. (1998). The prevalence of complementary alternative medicine in cancer: A systematic review. <i>Cancer, 83</i>, 777-782.

Estes, J.D., Stolpman, D., Olyaei, A., Corless, C.L., Ham, J.M., Schwartz, J.M., et al. (2003). High prevalence of potentially hepatotoxic herbal supplement use in patients with fulminant hepatic failure. <i>Archives of Surgery, 138</i>, 852-858.

Evans, B.A., Griffiths, K., & Morton, M.S. (1995). Inhibition of 5 alpha-reductase in genital skin fibroblasts and prostate tissue by dietary lignans and isoflavonoids. <i>Journal of Endocrinology, 147</i>, 295-302.

Facts and Comparisons. (2001). <i>The Lawrence review of natural products-monograph system.</i> St. Louis, MO: Walter Kluwer.

Ferrara, L.A., Raimondi, A.S., D'Episcopo, L., Guido, L., Dello Russo, A., & Marotta, T. (2000). Olive oil and reduced need for antihypertensive medications. <i>Archives of Internal Medicine, 160</i>, 837-842.

Fetrow, C.W., & Avila, J.R. (1999). <i>Professional's handbook of complementary and alternative medicines.</i> Springhouse, PA: Springhouse.

Fontenele, J.B., Araujo, G.B., de Alencar, J.W., & Viana, G.S. (1997). The analgesic and anti-inflammatory effects of shark cartilage are due to a peptide molecule and are nitric oxide (NO) system dependent. <i>Biological and Pharmaceutical Bulletin, 20</i>, 1151-1154.

Fontenele, J.B., Viana, G.S., Xavier-Filho, J., & de-Alencar, J.W. (1996). Anti-inflammatory and analgesic activity of a water-soluble fraction from shark cartilage. <i>Brazilian Journal of Medical and Biological Research, 29</i>, 643-646.

Foster, S., & Duke, J.A. (1990). <i>A field guide to medicinal plants.</i> New York: Houghton Mifflin.

Foster, S., & Tyler, V.E. (1993). <i>Tyler's honest herbal: A sensible guide to the use of herbs and related remedies</i> (3rd ed.). Binghamton, NY: Haworth Herbal Press.

Freeman, G.L. (1994). Psyllium hypersensitivity. <i>Annals of Allergy, 73</i>, 490-492.

Freeman, V.L., Meydani, M., Yong, S., Pyle, J., Flanigan, R.C., Waters, W.B., et al. (2000). Prostatic levels of fatty acids and the histopathology of localized prostate cancer. <i>Journal of Urology, 164</i>, 2168-2172.

Gann, P.H., Hennekens, C.H., Sacks, F.M., Grodstein, F., Giovannucci, E.L., & Stampfer, M.J. (1994). Prospective study of plasma fatty acids and risk of prostate cancer. <i>Journal of the National Cancer Institute, 86</i>, 281-286.

Gann, P.H., Ma, J., Giovannucci, E., Willett, W., Sacks, F.M., Hennekens, C.H., et al. (1999). Lower prostate cancer risk in men with elevated plasma lycopene levels: Results of a prospective analysis. <i>Cancer Research, 59</i>, 1225-1230.

Gennaro, A. (1995). <i>The science and practice of pharmacy</i> (19th ed.). Easton, PA: Mack.

Gerber, M. (1996). Fiber and breast cancer: Another piece of the puzzle—But still an incomplete picture. <i>Journal of the National Cancer Institute, 88</i>, 857-858.

Gerhardt, A.L., & Gallo, N.B. (1998). Full-fat rice bran and oat bran similarly reduce hypercholesterolemia in humans. <i>Journal of Nutrition, 128</i>, 865-869.

Gesensway, D. (2000). Vitamin D. <i>Annals of Internal Medicine, 133</i>, 318.

Ghoneum, M. (1998). Enhancement of human natural killer cell activity by modified arabinoxylane from rice bran (MGN-3). <i>International Journal of Immunotherapy, 14</i>, 89-99.

Giovannucci, E. (1999). Tomatoes, tomato-based products, lycopene, and cancer: Review of the epidemiologic literature. <i>Journal of the National Cancer Institute, 91</i>, 317-331.

Giovannucci, E., Asherio, A., Rimm, E.B., Stampfer, M.J., Colditz, G.A., & Willett, W.C. (1995). Intake of cartenoids and retinol in relation to risk of prostate cancer. <i>Journal of the National Cancer Institute, 87</i>, 1767-1776.

Giovannucci, E., Leitzmann, M., Speigelmann, D., Rimm, E.B., Colditz, G.A., Stampfer, M.J., et al. (1998). A prospective study of physical activity and prostate cancer in male health professionals. <i>Cancer Research, 58</i>, 5117-5122.

Gomes, E.M., Souto, P.R., & Felzenszwalb, I. (1996). Shark-cartilage containing preparation protects cells against hydrogen peroxide induced damage and mutagenesis. <i>Mutation Research, 367</i>, 204-208.

Gordon, D.W., Rosenthal, G., Hart, J., Sirota, R., & Baker, A.L. (1995). Chaparral ingestion: The broadening spectrum of liver injury caused by herbal medications. <i>JAMA, 273</i>, 489-490.

Govers, M.J., Gannon, N.J., Dunshea, F.R., Gibson, P.R., & Muir, J.G. (1999). Wheat bran affects the site of fermentation of resistant starch and luminal indexes related to colon cancer risk: A study in pigs. <i>Gut, 45</i>, 840-847.

Gradelet, S., Le Bon, A.M., Berges, R., Suschetet, M., & Astorg, P. (1998). Dietary carotenoids inhibit aflatoxin B<sub>1</sub>-induced liver preneoplastic foci and DNA damage in the rat: Role of the modulation of aflatoxin B<sub>1</sub> metabolism. <i>Carcinogenesis, 19</i>, 403-411.

Grubbs, C.J., Steele, V.E., Casebolt, T., Juliana, M.M., Eto, I., Whitaker, L.M., et al. (1995). Chemoprevention of chemically-induced mammary carcinogenesis by indole-3-carbinol. <i>Anticancer Research, 15</i>, 709-716.

Gruenwald, J., Brendler, T., & Jaenicke, C. (Eds.). (1998). <i>PDR® for herbal medicines.</i> Montvale, NJ: Medical Economics.

Gupta, S., Ahmad, N., & Mukhtar, H. (1999). Prostate chemoprevention by green tea. <i>Seminars in Urologic Oncology, 17</i>, 70-76.

Hakkak, R., Korourian, S., Shelnutt, S.R., Lensing, S., Ronis, M.J., & Badger, T.M. (2000). Diets containing whey proteins or soy protein isolate protect against 7, 12-dimethylbenz(a)anthracene-induced mammary tumors in female rats. <i>Cancer Epidemiology, Biomarkers and Prevention, 9</i>, 113-117.

Hardman, J.G., & Limbird, L.L. (Eds.). (1996). <i>Goodman and Gilman's the pharmacological basis of therapeutics</i> (9th ed.) New York: McGraw-Hill.

Harkins, K. (2000). What's the use of cranberry juice? <i>Age and Ageing, 29</i>(1), 9-12.

Harvei, S., Bjerve, K.S., Tretli, S., Jellu, E., Robsahm, T.E., & Vatten, L. (1997). Prediagnostic level of fatty acids in serum phospholipids: Omega-3 and omega-6 fatty acids and the risk of prostate cancer. <i>International Journal of Cancer, 71</i>, 545-551.

Hay, K.D., & Greig, D.E. (1990). Propolis allergy: A cause of oral mucositis with ulceration. <i>Oral Surgery, Oral Medicine, and Oral Pathology, 70</i>, 584-586.

He, K., Zhao, G.X., Shi, G., Zeng, L., Chao, J.F., & McLaughlin, J.L. (1997). Additional bioactive annonaceous acetogenins from Asminia triloba (Annonaceae). <i>Bioorganic and Medicinal Chemistry, 5</i>, 501-506.

He, Y.H., Friesen, M.D., Ruch, R.J., & Schut, H.A. (2000). Indole-3-carbinol as a chemopreventive agent in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) carcinogenesis: Inhibition of PhIP-DNA adduct formation, acceleration of PhIP metabolism, and induction of cytochrome P450 in female F344 rats. <i>Food and Chemical Toxicology, 38</i>(1), 15-23.

Health and Welfare Canada. (1990). <i>Nutrition recommendations.</i> Ottawa: Canadian Government Publishing Centre.

Herbert, V. (1981). <i>Nutrition cultism facts and fictions.</i> Philadelphia: Stickley.

Herschler, R. (1986). <i>U.S. Patent No. 4,616,039</i>. Washington, DC: U.S. Patent and Trademark Office.

Holzgartner, H., Schmidt, U., & Kuhn, U. (1992). Comparison of the efficacy and tolerance of a garlic preparation vs. bezafibrate. <i>Arzneimittel-Forschung, 42</i>, 1473-1477.

Hu, F.B., Stampfer, M.J., Manson, J.E., Rimm, E.B., Wolk, A., Colditz, G.A., et al. (1999). Dietary intake of alpha-linolenic acid and risk of fatal ischemic heart disease among women. <i>American Journal of Clinical Nutrition, 69</i>, 890-897.

Huang, D.S., Odeleye, O.E., & Watson, R.R. (1992). Inhibitor effects of canthaxanthin on in vitro growth of murine tumor cells. <i>Cancer Letters, 65</i>, 209-213.

Huang, K.C. (1999). <i>The pharmacology of Chinese herbs</i> (2nd ed.). Boca Raton, FL: CRC Press.

Huang, Z., Fasco, M.J., & Kaminsky, L.S. (1997). Inhibition of estrone sulfatase in human liver microsomes by quercetin and other flavonoids. <i>Journal of Steroid Biochemistry and Molecular Biology, 63</i>(1-3), 9-15.

Hunt, T.J., & Connelly, J.F. (1995). Shark cartilage for cancer treatment. <i>American Journal of Health-System Pharmacy, 52</i>, 1756-1760.

Ide, N., & Lau, B.H. (1997). Garlic compounds protect vascular endothelial cells from oxidized low density lipoprotein-induced injury. <i>Journal of Pharmacy and Pharmacology, 49</i>, 908-911.

Ide, N., & Lau, B.H. (1999). Aged garlic extract attenuates intracellular oxidative stress. <i>Phytomedicine, 6</i>, 125-131.

Imai, J., Ide, N., Nagae, S., Moriguchi, T., Matsuura, H., & Itakura, Y. (1994). Antioxidant and radical scavenging effects of aged garlic extract and its constituents. <i>Planta Medica, 60</i>, 417-420.

Jackson, B., & Hicks, L.E. (1997). Effect of cranberry juice on urinary pH in older adults. <i>Home Healthcare Nurse, 15</i>, 199-202.

Jacobsen, B.K., Knutsen, S.F., & Fraser, G.E. (1998). Does high soy milk intake reduce prostate cancer incidence? <i>Cancer Causes and Control, 9</i>, 553-557.

Jain, A.K., Vargas, R., Gotzkowsky, S., & McMahon, F.G. (1993). Can garlic reduce levels of serum lipids? A controlled clinical study. <i>American Journal of Medicine, 94</i>, 632-635.

Katiyar, S.K., Ahmad, N., & Mukhtar, N. (2000). Green tea and skin. <i>Archives of Dermatology, 136</i>, 989-994.

Katz, M., & Saibil, F. (1990). Herbal hepatitis: Subacute hepatic necrosis secondary to chaparral leaf. <i>Journal of Clinical Gastroenterology, 12</i>, 203-206.

Kennedy, R.S., Konok, G.P., Bounous, G., Baruchel, S., & Lee, T.D. (1995). The use of a whey protein concentrate in the treatment of patients with metastatic carcinoma: A phase I-II clinical study. <i>Anticancer Research, 15</i>, 2643-2649.

Keys, A., Menotti, A., Karvonen, M.J., Aravanis, C., Blackburn, H., Buzina, R., et al. (1986). The diet and 15-year death rate in the seven countries study. <i>American Journal of Epidemiology, 124</i>, 903-915.

Kim, D.J., Han, B.S., Ahn, B., Hasegawa, R., Shirai, T., Ito, N., et al. (1997). Enhancement by indole-3-carbinol of liver and thyroid gland neoplastic development in a rate medium-term multiorgan carcinogenesis model. <i>Carcinogenesis, 18</i>, 377-381.

King, D.S., Sharp, R.L., Vukovich, M.D., Brown, G.A., Reifenrath, T.A., Uhl, N.L., et al. (1999). Effects of oral androstenedione on serum testosterone and adaptations to resistance training in young men: A randomized controlled trial. <i>JAMA, 281</i>, 2020-2028.

Klein, V., Chajes, V., Germain, E., Schulgen, G., Pinault, M., Malvy, D., et al. (2000). Low alpha-linolenic acid content of adipose breast tissue is associated with an increased risk of breast cancer. <i>European Journal of Cancer, 36</i>, 335-340.

Klippel, K.F., Hiltl, D.M., & Schipp, B. (1997). A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. <i>British Journal of Urology, 80</i>, 427-432.

Kojima, T., Tanaka, T., & Mori, H. (1994). Chemoprevention of spontaneous endometrial cancer in female Donryu rats by dietary indole-3-carbinol. <i>Cancer Research, 54</i>, 1446-1449.

Kolonel, L.N., Nomura, A.M., & Cooney, R.V. (1999). Dietary fat and prostate cancer: Current status. <i>Journal of the National Cancer Institute, 91</i>, 414-428.

Kuno, Y., Kawabe, Y., & Sakakibara, S. (1999). Allergic contact dermatitis associated with photosensitivity, from alantolactone in a chrysanthemum farmer. <i>Contact Dermatitis, 40</i>, 224-225.

L'Allemain, G. (1999). Les multiples actions de l'EGCG anti-oxydant tiré du thé vert [Multiple actions of EGCG, the main component of green tea]. <i>Bulletin du Cancer, 86</i>, 721-724.

Lane, I.W., & Comac, L. (1992). <i>Sharks don't get cancer.</i> Garden City, NY: Avery.

Lashner, B.A. (1993). Red blood cell folate is associated with the development of dysplasia and cancer in ulcerative colitis. <i>Journal of Cancer Research and Clinical Oncology, 119</i>, 549-554.

la Vecchia, C., Negri, E., Franceschi, S., Decrali, A., Giacosa, A., & Lipworth, L. (1995). Olive oil, other dietary fats, and the risk of breast cancer. <i>Cancer Causes and Control, 6</i>, 545-550.

Lean, M.E., Noroozi, M., Kelly, I., Burns, J., Talwar, D., Sattar, N., et al. (1999). Dietary flavonols protect diabetic human lymphocytes against oxidative damage to DNA. <i>Diabetes, 48</i>, 176-181.

Lee, I.P., Kim, Y.H., Kang, M.H., Roberts, C., Shim, J.S., & Roh, J.K. (1997). Chemopreventive effect of green tea (Camellia sinesis) against cigarette smoke-induced mutations (SCE) in humans. <i>Journal of Cellular Biochemistry Supplement, 27</i>, 68-75.

Lee, S.K., Song, L., Mata-Greenwood, E., Kelloff, G.J., Steele, V.E., & Pezzuto, J.M. (1999). Modulation of in vitro biomarkers of the carcinogenic process by chemopreventive agents. <i>Anticancer Research, 19</i>, 441-449.

LeMarchand, L., Murphy, S.P., Hankin, J.H., Wilkens, L.R., & Kolonel, L.N. (2000). Intake of flavonoids and lung cancer. <i>Journal of the National Cancer Institute, 92</i>, 154-160.

Leung, A.Y., & Foster, S. (1996). <i>Encyclopedia of common natural ingredients used in food, drugs, and cosmetics</i> (2nd ed.). New York: John Wiley and Sons.

Li, M.K., Blacklock, N.J., & Garside, J. (1985). Effects of magnesium on calcium oxalate crystallization. <i>Journal of Urology, 133</i>, 123-125.

Luo, D.Y. (1992). Inhibitory effect of refined Amorphophallus konjac on MNNG-induced lung cancer in mice. <i>Zhonghua Zhong Liu Za Zhi, 14</i>, 48-50.

Martindale, W. (1999). <i>Martindale: The extra pharmacopoeia.</i> London: Royal Pharmaceutical Society, Pharmaceutical Press.

Massey, L.K., Palmer, R.G., & Horner, H.T. (2001). Oxalate content of soybean seeds (Glycine max: Leguminosae), soyfoods, and other edible legumes. <i>Journal of Agricultural and Food Chemistry, 49</i>, 4262-4266.

McCabe, D., O'Dwyer, P., Sickle-Santanello, B., Woltering, E., Abou-Issa, H., & James, A. (1986). Polar solvents in the chemoprevention of dimethylbenzanthracene-induced rate mammary cancer. <i>Archives of Surgery, 121</i>, 1455-1459.

McDonald, R.W., Bunjobpon, W., Liu, T., Fessler, S., Pardo, O.E., Freer, I.K., et al. (2001). Synthesis and anticancer activity of nordihydroguaiaretic acid (NDGA) and analogues. <i>Anticancer Drug Design, 16</i>, 261-270.

McIntosh, G.H. (1993). Colon cancer: Dietary modifications required for a balanced protective diet. <i>Preventive Medicine, 22</i>, 767-774.

McKevoy, G.K. (Ed.). (1998). <i>AHFS drug information.</i> Bethesda, MD: American Society of Health-System Pharmacists.

McMichael-Phillips, D.F., Harding, C., Morton, M., Roberts, S.A., Howell, A., Potten, C.S., et al. (1998). Effects of soy-protein supplementation on epithelial proliferation in the histologically normal human breast. <i>American Journal of Clinical Nutrition, 68</i>(6, Suppl.), 1431S-1435S.

McRorie, J., Kesler, J., Bishop, L., Filloon, T., Allgood, G., Sutton, M., et al. (2000). Effects of wheat bran and Olestra on objective measures of stool and subjective reports of GI symptoms. <i>American Journal of Gastroenterology, 95</i>, 1244-1252.

Michaud, D.S., Feskanich, D., Rimm, E.G., Colditz, G.A., Speizer, F.E., Willett, W.C., et al. (2000). Intake of specific carotenoids and risk of lung cancer in 2 prospective U.S. cohorts. <i>American Journal of Clinical Nutrition, 72</i>, 990-997.

Michnovicz, J.J. (1998). Increased estrogen 2-hydrozylation in obese women using oral indole-3-carbinol. <i>International Journal of Obesity and Related Metabolic Disorders, 22</i>, 227-229.

Michnovicz, J.J., & Bradlow, H.L. (1990). Induction of estrogen metabolism by dietary indole-3-carbinol in humans. <i>Journal of the National Cancer Institute, 82</i>, 947-949.

Micromedex Inc. (2004). <i>Micromedex healthcare series.</i> Englewood, CO: Author.

Miller, D.R., Anderson, G.T., Stark, J.J., Granick, J.L., & Richardson, D. (1998). Phase I/II trial of the safety and efficacy of shark cartilage in the treatment of advanced cancer. <i>Journal of Clinical Oncology, 16</i>, 3649-3655.

Miodini, P., Floravanti, L., Di Fronzo, G., & Cappelletti, V. (1999). The two phyto-oestrogens genistein and quercetin exert different effects on oestrogen receptor function. <i>British Journal of Cancer, 80</i>, 1150-1155.

Montbriand, M.J. (1994). <i>Decision heuristics of patients with cancer: Alternate and biomedical choices.</i> Unpublished doctoral dissertation, University of Saskatchewan, Saskatoon, Canada.

Montbriand, M.J. (1995a). Alternative therapies as control behaviors used by cancer patients. <i>Journal of Advanced Nursing, 22</i>, 646-654.

Montbriand, M.J. (1995b). Decision tree model describing alternate health care choices made by oncology patients. <i>Cancer Nursing, 18</i>, 104-117.

Montbriand, M.J. (1997). Empowerment of seniors through improved communication about medication. In L.F. Heumann (Ed.), <i>Proceedings of the Sixth International Conference on Systems Science in Health-Social Services for the Elderly and the Disabled</i> (pp. 258-264). Chicago: University of Illinois of Urbana-Champaign.

Montbriand, M.J. (2000a). Health professionals' attitudes about alternative therapies. <i>Canadian Nurse, 96</i>, 22-26.

Montbriand, M.J. (2000b). Senior and health-professionals' mismatched perceptions and communication about prescription and non-prescription medication. <i>Canadian Journal on Aging, 19</i>, 35-56.

Montbriand, M.J. (2004a). Herbs or natural products that decrease cancer growth: Part one of a four-part series. <i>Oncology Nursing Forum, 31</i>, E75-E90.

Montbriand, M.J. (2004b). Herbs or natural products that increase cancer growth or recurrence: Part two of a four-part series. <i>Oncology Nursing Forum, 31</i>, E99-E115.

Moriguchi, T., Saito, H., & Nishiyama, N. (1996). Aged garlic extract prolongs longevity and improves spatial memory deficit in senescence-accelerated mouse. <i>Biological and Pharmaceutical Bulletin, 19</i>, 305-307.

Murray, M., & Pizzorno, J. (1998). <i>Encyclopedia of natural medicine</i> (2nd ed.). Rocklin, CA: Prima Health.

Natural Medicines Comprehensive Database. (2004). Therapeutic Research National Faculty database [Data file]. Available at <a target="_blank" href='http://www.naturaldatabase.com'>http://www.naturaldatabase.com</a>

Newall, C.A., Anderson, L.A., & Philpson, J.D. (1996). <i>Herbal medicine: A guide for health care professionals.</i> London: Pharmaceutical Press.

O'Dwyer, P.J., McCabe, D.P., Sickle-Santanello, B.J., Woltering, E.A., Clausen, K., & Martin, E.W., Jr. (1988). Use of polar solvents in chemoprevention of 1,2-dimethylhydrazine-induced colon cancer. <i>Cancer, 62</i>, 944-948.

Ohkawa, T., Ebisuno, S., Kitagawa, M., Morimoto, S., & Miyazaki, Y. (1983). Rice bran treatment for hypercalciuric patients with urinary calculous disease. <i>Journal of Urology, 129</i>, 1009-1011.

Ohkawa, T., Ebisuno, S., Kitagawa, M., Morimoto, S., Miyazaki, Y., & Yasukawa, S. (1984). Rice bran treatment for patients with hypercaldiuric stones: Experimental and clinical studies. <i>Journal of Urology, 132</i>, 1140-1145.

O'Shea, M., Stanton, C., & Devery, R. (1999). Antioxidant enzyme defense responses of human MCF-7 and SW480 cancer cells to conjugated linoleic acid. <i>Anticancer Research, 19</i>, 1953-1960.

Papenburg, R., Bounous, G., Fleiszer, D., & Gold, P. (1990). Dietary milk proteins inhibit the development of dimethylhydrazine-induced malignancy. <i>Tumor Biology, 11</i>, 129-136.

Pariza, M., Park, Y., & Cook, M.E. (1999). Conjugated linoleic acid and the control of cancer and obesity. <i>Toxicological Sciences, 52</i>(2, Suppl.), 107-110.

Paulsen, E., Sogaard, J., & Andersen, K.E. (1998). Occupational dermatitis in Danish gardeners and greenhouse workers (III). Compositae-related symptoms. <i>Contact Dermatitis, 38</i>, 140-146.

Pence, B.C., Buddingh, F., & Yang, S.P. (1986). Multiple dietary factors in the enhancement of dimethylhydrazine carcinogenesis: Main effect of the indole-3-carbinol. <i>Journal of the National Cancer Institute, 77</i>, 269-276.

Perlman, A.I., Eisenberg, D.M., & Panush, R.S. (1999). Talking with patients about alternative and complementary medicine. <i>Rheumatic Disease Clinics of North America, 25</i>, 815-822.

Petrakis, N.L., Barnes, S., King, E.B., Lowenstein, J., Wiencke, J., Lee, M.M., et al. (1996). Stimulatory influence of soy protein isolate on breast secretion in pre- and postmenopausal women. <i>Cancer Epidemiology, Biomarkers and Prevention, 5</i>, 785-794.

Pierre, F., Perrin, P., Champ, M., Bornet, F., Meflah, K., & Menanteau, J. (1997). Short-chain fructo-oligosaccharides reduce the occurrence of colon tumors and develop gut-associated lymphoid tissue in Min mice. <i>Cancer Research, 57</i>, 225-228.

Pratt, S. (1999). Dietary prevention of age-related macular degeneration. <i>Journal of the American Optomology Association, 70</i>, 39-47.

Ramon, J.M., Bou, R., Romea, S., Alkiza, M.E., Jacas, M., Ribes, J., et al. (2000). Dietary fat intake and prostate cancer risk: A case-control study in Spain. <i>Cancer Causes and Control, 11</i>, 679-685.

Rao, A.V., & Agarwal, S. (1998). Bioavailability and in vivo antioxidant properties of lycopene from tomato products and their possible role in the prevention of cancer. <i>Nutrition and Cancer, 31</i>, 199-203.

Rao, A.V., & Agarwal, S. (2000). Role of antioxidant lycopene in cancer and heart disease. <i>Journal of the American College of Nutrition, 19</i>, 563-569.

Robbers, J.E., & Tyler, V.E. (1999). <i>Tyler's herbs of choice: The therapeutic use of phytomedicinals.</i> New York: Haworth Herbal Press.

Roberfroid, M.B. (2000). Prebiotics and probiotics: Are they functional foods? <i>American Journal of Clinical Nutrition, 71</i>(6, Suppl.), 1682S-1687S.

Rosen, C.A., Woodson, G.E., Thompson, J.W., Hengesteg, A.P., & Bradlow, H.L. (1998). Preliminary results of the use of indole-3-carbinol for recurrent respiratory papillomatosis. <i>Otolaryngology and Head and Neck Surgery, 118</i>, 810-815.

Salomi, N.J., Nair, S.C., Jayawardhanan, K.K., Varghese, C.D., & Panikkar, K.R. (1992). Antitumour principles from Nigella sativa seeds. <i>Cancer Letters, 63</i>, 41-46.

Sato, T., & Miyata, G. (2000). The nutraceutical benefit, part IV: Garlic. <i>Nutrition, 16</i>, 787-788.

Sauvaire, Y., Petit, P., Broca, C., Manteghetti, M., Baissac, Y., Fernandez-Alvarez, J., et al. (1998). 4-hydroxyisoleucine. A novel amino acid potentiator of insulin secretion. <i>Diabetes, 47</i>, 206-210.

Schneider, R.P. (1989). Perdiem causes esophageal impaction and bezoars. <i>Southern Medical Journal, 82</i>, 1449-1450.

Schulz, V., Hansel, R., & Tyler, V.E. (1998). <i>Rational phytotherapy: A physician's guide to herbal medicine</i> (3rd ed.) (T.C. Telger, Trans.). Berlin, Germany: Springer.

Sebedio, J.L., Gnaedig, S., & Chardigny, J.M. (1999). Recent advances in conjugated linoleic acid research. <i>Current Opinion in Clinical Nutrition and Metabolic Care, 2</i>, 499-506.

Sheikh, N.M., Philen, R.M., & Love, L.A. (1997). Chaparral-associated hepatotoxicity. <i>Archives of Internal Medicine, 157</i>, 913-919.

Shoskes, D.A., Zeitlin, S.I., Shahed, A., & Rajfer, J. (1999). Quercetin in men with category III chronic prostatitis: A preliminary prospective, double-blind, placebo-controlled trial. <i>Urology, 54</i>, 960-963.

Sigounas, G., Hooker, J., Anagnostou, A., & Steiner, M. (1997). S-allylmercaptocysteine inhibits cell proliferation and reduces the viability of erythroleukemia, breast, and prostate cancer cell lines. <i>Nutrition and Cancer, 27</i>, 186-191.

Silagy, C., & Neil, A. (1994). Garlic as a lipid lowering agent—A meta-analysis. <i>Journal of the Royal College of Physicians of London, 28</i>, 39-45.

Simopoulos, A.P. (1999). Essential fatty acids in health and chronic disease. <i>American Journal of Clinical Nutrition, 70</i>(3, Suppl.), 560S-569S.

Slattery, M.L., Potter, J.D., Coates, A., Ma, K.N., Berry, T.D., Duncan, D.M., et al. (1997). Plant foods and colon cancer: An assessment of specific foods and their related nutritions (United States). <i>Cancer Causes and Control, 8</i>, 575-590.

Smolinske, S.C. (1999). Dietary supplement-drug interactions. <i>Journal of the American Medical Women's Association, 54</i>, 191-192, 195.

Snodderly, D.M. (1995). Evidence for protection against age-related macular degeneration by carotenoids and antioxidant vitamins. <i>American Journal of Clinical Nutrition, 62</i>(6, Suppl.), 1448S-1461S.

Sommerburg, O., Keunen, J.E., Bird, A.C., & van Kuijk, F.J. (1998). Fruits and vegetables that are sources for lutein and zeaxanthin: The macular pigment in human eyes. <i>British Journal of Opthalmology, 82</i>, 907-910.

Sparber, A., Bauer, L., Curt, G., Eisenberg, D., Levin, T., Parks, S., et al. (2000). Use of complementary medicine by adult patients participating in cancer clinical trials. <i>Oncology Nursing Forum, 27</i>, 887-888.

Sparber, A., & Wootton, J.C. (2001). Surveys of complementary and alternative medicine: Part II. Use of alternative and complementary cancer therapies. <i>Journal of Alternative and Complementary Medicine, 7</i>, 281-287.

Sporn, M.B. (2000). Retinoids and demethylating agents—Looking for partners. <i>Journal of the National Cancer Institute, 92</i>, 780-781.

Steinmetz, K.A., & Potter, J.D. (1991). Vegetables, fruit, and cancer. 1. Epidemiology. <i>Cancer Causes and Control, 8</i>, 575-590.

Stone-Dorshow, T., & Levitt, M.D. (1987). Gaseous response to ingestion of a poorly absorbed fructo-oligosaccharide sweetener. <i>American Journal of Clinical Nutrition, 46</i>, 61-65.

Stoneham, M., Goldacre, M., Seagroatt, V., & Gill, L. (2000). Olive oil, diet and colorectal cancer: An ecological study and a hypothesis. <i>Journal of Epidemiology and Community Health, 54</i>, 756-760.

Suhonen, R., Kantola, I., & Bjorksten, F. (1983). Anaphylactic shock due to ingestion of psyllium laxative. <i>Allergy, 38</i>, 363-365.

Tanaka, T., Makita, H., Ohnishi, M., Mori, H., Satoh, K., & Hara, A. (1995). Chemoprevention of rat oral carcinogenesis by naturally occurring xanthophylis, astaxanthin, and canthaxanthin. <i>Cancer Research, 55</i>, 4059-4064.

Tanaka, T., Morishita, Y., Suzui, M., Kojima, T., Okumura, A., & Mori, H. (1994). Chemoprevention of mouse urinary bladder carcinogenesis by the naturally occurring carotenoid astaxanthin. <i>Carcinogenesis, 15</i>, 15-19.

Taylor, J.R., & Wilt, V.M. (1999). Probable antagonism of warfarin by green tea. <i>Annals of Pharmacotherapy, 33</i>, 426-428.

Trevisan, M., Krogh, V., Frudenheim, J., Blake, A., Muti, P., Panico, S., et al. (1990). Consumption of olive oil, butter, and vegetable oils and coronary heart disease risk factors. The Research Group ATS-RF2 of the Italian National Research Council. <i>JAMA, 263</i>, 688-692.

Tsubono, Y., Nishino, Y., Komatsu, S., Hsieh, C.C., Kanemura, S., Tsuji, I., et al. (2001). Green tea and the risk of gastric cancer in Japan. <i>New England Journal of Medicine, 344</i>, 632-636.

Tyler, V.E. (1993). <i>The honest herbal</i> (3rd ed.). Binghamton, NY: Pharmaceutical Products Press.

Tyler, V.E. (1994). <i>Herbs of choice: The therapeutic use of phytomedicinals.</i> Binghamton, NY: Pharmaceutical Products Press.

Tyler, V.E., Brady, L.R., & Robbers, J.B. (1981). <i>Pharmacognosy.</i> Philadelphia: Lea and Fibiger.

Tzanakakis, G.N., Agarwal, K.C., & Vezeridis, M.P. (1990). Inhibition of hepatic metastasis from a human pancreatic adenocarcinoma (RWP-2) in the nude mouse by prostacyclin, forskolin, and ketoconazole. <i>Cancer, 65</i>, 446-451.

Tzonou, A., Signorello, L.B., Lagiuo, P., Wuu, J., Trichopoulos, D., & Trichopoulou, A. (1999). Diet and cancer of the prostate: A case-control study in Greece. <i>International Journal of Cancer, 80</i>, 704-708.

Vainio, H., & Rautalahti, M. (1998). An international evaluation of the cancer preventive potential of carotenoids. <i>Cancer Epidemiology, Biomarkers and Prevention, 7</i>, 725-728.

Walsh, D.E., Yaghoubian, V., & Behforooz, A. (1984). Effect of glucomannan on obese patients: A clinical study. <i>International Journal of Obesity, 8</i>, 289-293.

Watkins, T.R., Geller, M., Kooyenga, D.K., & Bierenbaum, M.L. (1999). Hypocholesterolemic and antioxidant effect of rice bran oil non-saponifiables in hypercholesterolemic subjects. <i>Environmental and Nutritional Interactions, 3</i>, 115-122.

Weisburger, J.H., Reddy, B.S., Rose, D.P., Cohen, L.A., Kendall, M.E., & Wynder, E.L. (1993). Protective mechanisms of dietary fibers in nutritional carcinogenesis. <i>Basic Life Science, 61</i>, 45-63.

White, J.D. (2002). Complementary and alternative medicine research: A National Cancer Institute perspective. <i>Seminars in Oncology, 29</i>, 546-551.

Widschwendter, M., Berger, J., Hermann, M., Muller, H.M., Amberger, A., Zeschnigk, M., et al. (2000). Methylation and silencing of the retinoic acid receptor-beta2 gene in breast cancer. <i>Journal of the National Cancer Institute, 82</i>, 826-832.

Wong, G.Y., Bradlow, L., Sepkovic, D., Mehl, S., Mailman, J., & Osborne, M.P. (1997). Dose-ranging study of indole-3-carbinol for breast cancer prevention. <i>Journal of Cellular Biochemistry Supplement, 28-29</i>, 111-116.

Yates, A.A., Schlicker, S.A., & Suitor, C.W. (1998). Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. <i>Journal of the American Dietetic Association, 98</i>, 699-706.

Yen, C.L., Mar, M.H., & Zeisel, S.H. (1999). Choline deficiency-induced apoptosis in PC12 cells is associated with diminished membrane phosphat-dylcholine and sphingomyelin, accumulation of ceramide and diacylglycerol, and activiation of a caspase. <i>FASEB Journal, 13</i>, 135-142.

Yu, X.Y. (1993). A prospective clinical study on reversion of 200 precancerous patients with hua-sheng-ping. <i>Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi, 13</i>, 147-149.

Yuan, F., Chen, D.Z., Liu, K., Sepkovic, D.W., Bradlow, H.L., & Auborn, K. (1999). Anti-estrogenic activities of indole-3-carbinol in cervical cells: Implication for prevention of cervical cancer. <i>Anticancer Research, 19</i>, 1673-1680.

Zeisel, S.H. (1992). Choline: An important nutrient in brain development, liver function and carcinogenesis. <i>Journal of the American College of Nutrition, 11</i>, 473-481.

Zhang, Y., Moriguchi, T., Saito, H., & Nishiyama, N. (1998). Functional relationship between age-related immunodeficiency and learning deterioration. <i>New European Journal of Neuroscience, 10</i>, 3869-3875.