Genetics & Genomics

Microsatellite Testing in Colon Cancer

Suzanne M. Mahon
colorectal cancer, molecular testing, molecular pathways
ONF 2014, 41(3), 331-333. DOI: 10.1188/14.ONF.331-333

Significant progress has been made in understanding the molecular genetic basis of colorectal cancer (CRC). That information is paving the way to understanding the genetic basis of other tumors, as well. Oncology nurses should anticipate the routine integration of this information and testing of CRC tumors to understand the molecular basis of the disease in clinical practice. Molecular testing can lead to the identification of families at risk for hereditary cancer syndromes, particularly Lynch syndrome, which sometimes is referred to as hereditary nonpolyposis colorectal cancer. Knowledge of the genetic basis of CRC also contributes valuable information aimed at selecting appropriate and effective targeted therapy.

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    References

    Buecher, B., Cacheux, W., Rouleau, E., Dieumegard, B., Mitry, E., & Lièvre, A. (2013). Role of microsatellite instability in the management of colorectal cancers. Digestive and Liver Disease, 45, 441-449. doi:10.1016/j.dld.2012.10.006
    Burt, R.W., Cannon, J.A., David, D.S., Early, D.S., Ford, J.M., Giardiello, F.M., … Freedman-Cass, D. (2013). Colorectal cancer screening. Journal of the National Comprehensive Cancer Network, 11, 1538-1575.
    Gala, M., & Chung, D.C. (2011). Hereditary colon cancer syndromes. Seminars in Oncology, 38, 490-499.
    Gibson, J., Lacy, J., Matloff, E., & Robert, M. (2014). Microsatellite instability testing in colorectal carcinoma: A practical guide. Clinical Gastroenterology and Hepatology, 12, 171-176.
    Hall, M.J. (2010). Counterpoint: Implementing population genetic screening for Lynch Syndrome among newly diagnosed colorectal cancer patients—Will the ends justify the means? Journal of the National Comprehensive Cancer Network, 8, 606-611.
    Hampel, H. (2010). Point: Justification for Lynch Syndrome screening among all patients with newly diagnosed colorectal cancer. Journal of the National Comprehensive Cancer Network, 8, 597-601.
    Kalady, M.F. (2013). Sessile serrated polyps: An important route to colorectal cancer. Journal of the National Comprehensive Cancer Network, 11, 1585-1594.
    Kelley, R.K., Van Bebber, S.L., Phillips, K.A., & Venook, A.P. (2011). Personalized medicine and oncology practice guidelines: A case study of contemporary biomarkers in colorectal cancer. Journal of the National Comprehensive Cancer Network, 9, 13-25.
    Kloor, M., Staffa, L., Ahadova, A., & von Knebel Doeberitz, M. (2014). Clinical significance of microsatellite instability in colorectal cancer. Langenbeck's Archives of Surgery, 399(1), 23-31. doi:10.1007/s00423-013-1112-3
    Matloff, J., Lucas, A., Polydorides, A.D., & Itzkowitz, S.H. (2013). Molecular tumor testing for Lynch syndrome in patients with colorectal cancer. Journal of the National Comprehensive Cancer Network, 11, 1380-1385.
    Meguerditchian, A.N., & Bullard Dunn, K. (2013). Biomarkers and targeted therapeutics in colorectal cancer. Surgical Oncology Clinics of North America, 22, 841-855. doi:10.1016/j.soc.2013.07.002
    Power, D.G., Gloglowski, E., & Lipkin, S.M. (2010). Clinical genetics of hereditary colorectal cancer. Hematology/Oncology Clinics of North America, 24, 837-859.
    Rosner, G., & Strul, H. (2014). Should microsatellite instability be tested in all cases of colorectal cancer? Current Colorectal Cancer Reports, 10, 27-35. doi:10.1007/s11888-013-0204-3
    Senter, L. (2012). Genetic testing by cancer site: Colon (nonpolyposis syndromes). Cancer Journal, 18, 334-337.
    Serrano, M., Lage, P., Belga, S., Filipe, B., Francisco, I., Rodrigues, P., … Pereira, A.D. (2012). Bethesda criteria for microsatellite instability testing: Impact on the detection of new cases of Lynch syndrome. Familial Cancer, 11, 571-578.
    Umar, A., Boland, C.R., Terdiman, J.P., Syngal, S., de la Chapelle, A., Rüschoff, J., … Srivastava, S. (2004). Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. Journal of the National Cancer Institute, 96, 261-268.
    Weissman, S.M., Burt, R., Church, J., Erdman, S., Hampel, H., Holter, S., … Senter, L. (2012). Identification of individuals at risk for Lynch syndrome using targeted evaluations and genetic testing: National Society of Genetic Counselors and the Collaborative Group of the Americas on Inherited Colorectal Cancer joint practice guideline. Journal of Genetic Counseling, 21, 484-493. doi:10.1007/s10897-011-9465-7