Liao, S.F. (2015). Lymphedema characteristics and the efficacy of complex decongestive physiotherapy in malignant lymphedema. American Journal of Hospice and Palliative Care. Advance online publication.
To review the efficacy of complex decongestive physiotherapy (CDP) in patients with malignant lymphedema (LE) and to identify predictors for and characteristics of outcomes
Retrospective
Excess circumference decreased, and CDP efficacy as defined by the PREV was 46.6%. Pain scores improved from 4.8 to 2.8. Shoulder range of motion improved from a mean of 151.7 to 159.7.
The authors demonstrated that intensive CDP improved lymphedema volume, pain, heaviness, tension, and range of motion in a small study of patients with malignant LE.
Previous thoughts or teachings may have suggested that cancer could be spread by manual lymphatic drainage. This study shows the importance of early treatment in patients with malignant LE with CDP, providing improvements in limb volume and range of motion. Patient tolerance and variations in bandaging were not clearly identified in this study, and these may require modifications to the patient’s comfort level.
Liao, S.F., Li, S.H., Huang, H.Y., Chen, S.T., Kuo, S.J., Chen, D.R., & Wei, T.S. (2013). The efficacy of complex decongestive physiotherapy (CDP) and predictive factors of lymphedema severity and response to CDP in breast cancer-related lymphedema (BCRL). Breast, 22, 703–706.
To estimate the efficacy of and predictive factors for response to complete decongestive physical (CDP) therapy in women with breast cancer-related lymphedema
Retrospective review of records was done to describe results of a CDP program and analyze factors that might predict outcomes and CDP response. The CDP program consisted of 10–26 sessions of manual lymph drainage, compression therapy for 23 hours per day, remedial exercise, and skin and nail care instructions.
The study was conducted at a single-site, outpatient setting in Taiwan.
Patients were undergoing mutliple treatment phases of care.
The study used a retrospective, observational design.
Findings suggest that baseline lymphedema and age are significantly related to longer-term response to CDP for lymphedema management.
This study provides little new information regarding efficacy of CDP in management of lymphedema in women with breast cancer. Findings show that initial severity of lymphedema may predict response to CDP, which suggests that early intervention for lymphedema can be important.
Liao, S.F., Li, S.H., & Huang, H.Y. (2012). The efficacy of complex decongestive physiotherapy (CDP) and predictive factors of response to CDP in lower limb lymphedema (LLL) after pelvic cancer treatment. Gynecologic Oncology, 125(3), 712–715.
To evaluate the efficacy of an intensive complete decongestive physical (CDP) therapy program and identify predictive factors of response in lower-limb lymphedema
Women with unilateral LLL underwent a CDP program of 10–24 sessions that included 45 minutes of manual lymph drainage, compression therapy for 23 hours a day, and remedial exercise and instructions for skin and nail care.
The study was conducted at a single-site with multiple settings in Taiwan.
The study looked at mutliple phases of care.
The study used a retrospective review design.
Circumference measurements were used to calculate lymphedema volume.
Findings suggest that CDP is beneficial for management of lower-limb lymphedema. The lymphedema volume difference in the affected limb was directly correlated with response to CDP.
Findings suggest that CDP is beneficial for management of lower-limb lymphedema in patients treated for pelvic cancers. This is one of few studies for lower-limb lymphedema management. Nurses can educate and support patients in adhering to a CDP program to manage lymphedema. The authors noted that compliance with compression bandaging is a critical component of CDP, and nurses need to emphasize this with patients.
Liao, M.N., Chen, P.L., Chen, M.F., & Chen, S.C. (2010). Effect of supportive care on the anxiety of women with suspected breast cancer. Journal of Advanced Nursing, 66, 49–59.
To test the hypothesis that women with suspected breast cancer who received a supportive care intervention during the diagnostic phase of care would have lower anxiety than those having usual care
The intervention was supportive care, emotional support, and educational information provided by nurses through three individual meetings and two telephone calls.
Patients were undergoing the diagnostic phase of care.
A randomized controlled trial design was used.
State-Trait Anxiety Inventory (STAI)
Women in the intervention group had significantly lower state anxiety before biopsy and after learning the result compared to the control group (p = 0.008; p = 0.001).
Women with suspected breast cancer who received the supportive care program had lower anxiety than those receiving routine care.
Though resulting differences between groups were statistically significant, differences in scores between groups ranged from 1.14 to 2.12 on average, in a possible 80-point scale. The clinical relevance of this small difference is questionable, and the level of anxiety indicated by scores was still severe.
Liao, M.N., Chen, S.C., Lin, Y.C., Chen, M.F., Wang, C.H., & Jane, S.W. (2014). Education and psychological support meet the supportive care needs of Taiwanese women three months after surgery for newly diagnosed breast cancer: A non-randomised quasi-experimental study. International Journal of Nursing Studies, 51, 390–399.
To investigate the effects of education and psychological support on anxiety, symptom distress, social support, and unmet supportive care needs of Taiwanese women newly diagnosed with breast cancer over three months following surgery
Education and psychological support was provided in the form of three individual face-to-face sessions and two telephone follow-up sessions. A standardized educational booklet was used. Sessions were done at the first postoperative visit, the first chemotherapy session, and three months after surgery. The telephone follow-up call was made seven days before chemotherapy and two months after surgery. Study measures were obtained at baseline, one month after surgery, and three months after surgery.
Two-group, nonrandomized, quasiexperimental study
All forms were in Chinese.
The experimental group experienced lower levels of overall unmet supportive care needs and had lower levels of unmet needs in other dimensions as well. Levels of state anxiety and symptom distress also were lower in this group. Primary concerns across groups were self-care and supportive care. Anxiety declined in both groups at similar levels by the first follow-up measure. By three months after surgery, there was a greater reduction in anxiety scores in the experimental group, which were significantly lower than those of the control group (p < .001).
The educational and psychological support components of the intervention improved the unmet supportive care needs of patients newly diagnosed with breast cancer three months after surgery.
Li, M., Kennedy, E.B., Byrne, N., Gerin-Lajoie, C., Katz, M.R., Keshavarz, H., . . . Green, E. (2016). Systematic review and meta-analysis of collaborative care interventions for depression in patients with cancer. Psycho-Oncology. Advance online publication.
STUDY PURPOSE: To provide an evidence-based review to update treatment guidelines for depression in patients with cancer. Conducted analysis of pharmacologic and collaborative care interventions
TYPE OF STUDY: Meta-analysis and systematic review
PHASE OF CARE: Multiple phases of care
APPLICATIONS: Palliative care
All interventions examined had at least a short-term benefit for the treatment of depression. Pharmacologic interventions can be associated with adverse events, and psychological interventions had short-term efficacy but no long-term efficacy. Collaborative care interventions showed persistent benefit.
Pharmacologic, psychological, and collaborative care interventions demonstrated at least a short-term benefit for the treatment of depression among patients with cancer at various treatment phases. Collaborative care interventions showed strong and sustained effectiveness, suggesting that the integration of depression treatment into oncology settings can improve patient outcomes.
Li, X.J., Dai, Z.Y., Zhu, B.Y., Zhen, J.P., Yang, W.F., & Li, D.Q. (2014). Effects of sertraline on executive function and quality of life in patients with advanced cancer. Medical Science Monitor, 20, 1267–1273.
To determine the impact of sertraline on executive function and quality of life in patients with advanced stage cancer and depression
At baseline, patients were evaluated for high levels of depressive symptoms. Patients with high levels were assigned to the intervention group. Patients in the intervention group were prescribed sertraline hydrochloride at 25–75 mg daily for 12 weeks. The dose of sertraline was evaluated two weeks after initiation and titrated to a therapeutic level as necessary. All patients were assessed at baseline prior to the initiation of sertraline in the intervention group and at 12 weeks. Participants were restricted from taking medications that might affect their cognitive functioning for greater than three days.
Controlled trial with a pre- and post-trial design
At baseline, patients with depressive symptoms had significantly higher scores indicating lower executive functioning than non-depressed patients on total errors, perseverative errors, nonperseverative errors, and categories achieved (p < 0.01), but not failure to maintain set as measured by the WCST. In addition, these patients had greater anxiety (p < 0.01) as measured by the HAM-A and poorer quality of life (p < 0.01) in all eight dimensions measured by the SF-36. At the 12-week follow-up, although patients in the intervention group had decreased HAM-D and HAM-A scores, scores were still significantly higher than in the control group (p < 0.05). In contrast, there were no longer any significant differences in executive functioning between groups. Similarly, because patients in the intervention group had improved scores on the SF-36 (p < 0.05), there were no longer any significant differences in quality of life between groups.
Sertraline may improve executive functioning and quality of life in patients with cancer. This improvement may be mediated by improvements in depressive symptoms.
Sertraline may improve executive function and quality of life in patients with advanced stage cancer and depression. However, more research with larger sample sizes, randomized group assignments, and longer follow-up is warranted to determine whether the intervention is effective and sustainable.
Li, Q., Xu, Y., Zhou, H., & Loke, A.Y. (2015). A couple-based complex intervention for Chinese spousal caregivers and their partners with advanced cancer: An intervention study. Psycho-Oncology. Advance online publication.
To evaluate the acceptability and feasibility of a couples-based coping intervention, Caring for Couples Coping with Cancer (4Cs), and to gather preliminary data on the efficacy of the intervention
A convenience sample of couples received the 4Cs intervention, a couples-based intervention delivered weekly for six weeks by a researcher or therapist to small groups of couples (three to eight). The couples received semistructured instruction using information via didactic instruction, group sharing and group interaction. Sessions were supplemented using the guidebook Live With Love: Hope for the Best, Prepare for the Worst. Assessments were made at baseline and upon completing the six-week intervention.
Nonrandomized, pre- and postintervention study
The 4Cs cancer program for couples was easy to recruit for, had relatively low drop-out rate, and was well-tolerated by the participants. The couples showed significant increases in self-efficacy (p < 0.01), the DCI (p < 0.05), the PCS of SF12 (p < 0.05), and positive emotions on benefit finding (p < 0.05). Participants also experienced a significant decrease in overall CRCP (p < 0.05) and anxiety (p < 0.01).
The 4Cs program was feasible to administer to couples facing cancer and appeared to have preliminary data supporting its benefit for the emotional health and coping of couples dealing with cancer.
The 4Cs couples-based intervention shows promise for improving couple efficacy, coping, physical health, and positive emotions. Larger, multisite, randomized, controlled trials of this intervention are needed.
Li, Q., & Loke, A.Y. (2014). A systematic review of spousal couple-based intervention studies for couples coping with cancer: Direction for the development of interventions. Psycho-Oncology, 23, 731–739.
STUDY PURPOSE: To explore the existing interventions for spousal couples coping with cancer in terms of type of intervention, contents, approach, and outcome measurements, and to identify directions for the development of interventions
DATABASES USED: Science Citation Index Expanded, PsycInfo, MEDLINE via OVIS SP, CINAHL
KEYWORDS: intervention; program; therapy; cope; coping; cancer; oncology; carcinoma; couple; partner; spouse
INCLUSION CRITERIA: Published in English or Chinese within the four databases searched; couple-based interventions; studies had to focus on couple-based interventions; outcome measures included the patients with cancer and their spousal caregivers
EXCLUSION CRITERIA: Commentaries, editorials, literature reviews, conference proceedings
Of the 17 articles reviewed, interventions were focused mainly on patient caregiving and caregiver self-care, usually lasted for six weeks using a face-to-face group mode., and had follow-up around three months. The outcomes measures were grouped into three main dimensions: dyadic appraisal, dyadic coping, and dyadic adjustments. Positive outcomes were reported for these interventions, including improvements in communications, dyadic coping, quality of life of the patients and their partners, psychosocial distress, sexual functioning, marital satisfaction, and caregiver self efficacy. The majority of interventions were delivered to individual couples face-to-face. Attrition rate ranged from 6%–34%, with an average of 20%. Interventions were grouped as skills training (n = 11), counseling (n = 6), and psychoeducation (n = 2). Skills training and psychoeducation were most often provided together.
The findings highlighted the positive outcomes of couple-based interventions that focus on couples coping with cancer. Although all studies focused on the couple's communication and relationship, only 40% focused on the subject of the caregiver's self-care. All of the intervention studies included in the review reported positive outcomes to some extent, including quality of life, psychosocial distress, sexual functioning, and marital satisfaction of the patients and their partners.
Future couple-based intervention research should focus on patients with cancer whose spouse is an active caregiver and provide intervention and assessment of both partners as a unit (dyad). Findings from this review show that couple-based interventions had multiple benefits for patients and caregivers. The high attrition rates seen suggest that the most acceptable timing, duration, and method of delivery is not clear. Although benefit was shown, what factors would indicate those couples who would be most likely to benefit from couples interventions is not clear, and findings do not clarify which approaches are most beneficial.
Li, X.M., Zhou, K.N., Yan, H., Wang, D.L., & Zhang, Y.P. (2012). Effects of music therapy on anxiety of patients with breast cancer after radical mastectomy: A randomized clinical trial. Journal of Advanced Nursing, 68, 1145–1155.
To evaluate the effects of music therapy on anxiety in women undergoing breast cancer surgery
Patients admitted to the hospital for mastectomy were randomly assigned to receive either music therapy or usual care. Patients in the intervention group listened to music they selected through a headphone connected to an MP3 player during their hospital stay. Music was provided twice daily for 30 minutes per session. The total time in the hospital receiving therapy was an average of 13.6 days following radical mastectomy and 18.9 days for chemotherapy. Assessments were done at baseline on the day before surgery, the day before hospital discharge, on second hospital admission for chemotherapy, and on a third hospital admission for chemotherapy.
Patients were undergoing active antitumor treatment.
A randomized controlled trial design was used.
State Anxiety Inventory
Pretest results showed that patients had moderate to severe anxiety levels prior to surgery. Mean post-test anxiety scores were lower in the experimental group, on the first post-test 4.57 points, and increasing across time to 9.69 points lower at the final post-test (p < 0.0001). Mean anxiety scores declined over time in all patients.
Findings suggest that listening to music can be beneficial in reducing anxiety during treatment for breast cancer.
Listening to music is a simple and low-cost intervention that may be helpful for some patients in reducing anxiety associated with cancer treatment.