Colony-Stimulating Factors: G-CSF and GM-CSF Alteration in Schedule

Granulocyte–colony-stimulating factors (G-CSFs) and granulocyte macrophage–colony-stimulating factors (GM-CSF) are substances that bind to hematopoietic stem cells, activating them to proliferate and differentiate into granulocytes and macrophages—the specific cell type of interest. Colony-stimulating factors (CSFs) administered systemically have been evaluated and recommended for patients with cancer for the prevention of infection and febrile neutropenia. CSFs may be used for primary or secondary prophylaxis.