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ONS Guidelines Article
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Radiodermatitis in Patients With Cancer: Systematic Review and Meta-Analysis

Pamela K. Ginex
Chelsea Backler
Elizabeth Croson
Lindsey N. Horrell
Kerri A. Moriarty
Christine Maloney
Mark Vrabel
Rebecca L. Morgan
ONF 2020, 47(6), E225-E236 DOI: 10.1188/20.ONF.E225-E236

Problem Identification: A systematic review and meta-analysis was conducted to inform the development of guidelines on the management of radiodermatitis among patients with cancer.

Literature Search: The authors updated a systematic review to include available literature published through September 30, 2019.

Data Evaluation: Two investigators assessed risk of bias using the Cochrane Collaboration risk-of-bias tool and certainty of the evidence using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach.

Synthesis: The use of deodorant/antiperspirant had no effect on development of radiodermatitis. Aloe vera and emu oil were equivalent or less effective than standard care. Oral curcumin had a minimal beneficial effect. Nonsteroidal topical interventions had a minimal beneficial effect on the development of moist desquamation and relief of itching while causing a small increase for grade 2 radiodermatitis. Topical calendula increased risk for the development of radiodermatitis. Topical steroids and dressings each showed benefits to minimize the development of radiodermatitis and moist desquamation while lowering rates of patient-reported symptoms, such as pain and pruritus.

Implications for Research: Symptom management strategies for radiodermatitis among patients with cancer that are likely to be effective include topical nonsteroidals, topical steroids, and dressings.

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