0
No votes yet
Article

Heart Failure and Long-Term Survival Among Older Women With Breast Cancer

Jordan M. Harrison
Christopher R. Friese
Debra L. Barton
Nancy K. Janz
Susan J. Pressler
Matthew A. Davis
ONF 2018, 45(1), 77-87 DOI: 10.1188/18.ONF.77-87

Objectives: To evaluate the association between heart failure and overall survival up to 10 years after breast cancer diagnosis.

Sample & Setting: Women aged 65 years or older diagnosed with invasive breast cancer, with and without self-reported heart failure, were examined for this retrospective cohort study using Surveillance, Epidemiology, and End Results cancer registries in the United States.

Methods & Variables: Cox proportional hazards regression was used to examine the association between heart failure status and mortality, adjusting for comorbidity and other clinical or sociodemographic differences. Associations were examined overall and stratified by cancer stage.

Results: In adjusted models, having heart failure was associated with increased likelihood of death up to 10 years after cancer diagnosis. In adjusted subanalyses by cancer stage, heart failure was associated with increased likelihood of death up to 10 years after cancer diagnosis in women with stage I or II cancer but not in women with stage III/IV cancer.

Implications for Nursing: Although early-stage breast cancer is generally associated with better prognosis, the competing mortality risk of heart failure was greater for this group than for women with advanced cancer. Prevention and management of cardiovascular disease should be prioritized for this patient subgroup.

The co-occurrence of cancer and cardiovascular disease is a major public health issue that will become more prevalent as the population of older adults in the United States rapidly increases during the next several decades (Hung, Ross, Boockvar, & Siu, 2011, 2012; Smith, Smith, Hurria, Hortobagyi, & Buchholz, 2009). Women with breast cancer aged 65 years or older experience disproportionately high rates of heart failure. Increasing clinician concerns for patients with diagnoses of cancer and heart disease has catalyzed an emerging cross-disciplinary field of cardio-oncology (Moslehi, 2013, 2016). In a cohort study of more than 40,000 women diagnosed with breast cancer aged 66–70 years, the 10-year prevalence of heart failure ranged from 29% in women who received no chemotherapy to 38% in women treated with anthracyclines (Pinder, Duan, Goodwin, Hortobagyi, & Giordano, 2007). Comparatively, overall prevalence of heart failure in American women aged 60–79 years is 5% (Mozaffarian et al., 2016).

A growing body of evidence describes the complex interaction of factors that influence cardiovascular health in aging cancer survivors, including cancer treatment variables, lifestyle behaviors, and comorbid conditions (Leach, Bellizzi, Hurria, & Reeve, 2016; Leach et al., 2015; Patnaik, Byers, Diguiseppi, Denberg, & Dabelea, 2011). Multiple factors account for the high prevalence of heart failure in breast cancer survivors. Cardiovascular disease and breast cancer share many risk factors, including advanced age, obesity, and smoking (Lindenfeld & Kelly, 2010; Schmitz, Prosnitz, Schwartz, & Carver, 2012). The cardiotoxic effects of breast cancer therapies, including anthracyclines, mediastinal radiation, and biologic agents, such as trastuzumab, have been well documented (Lindenfeld & Kelly, 2010; Schmitz et al., 2012). Anthracycline chemotherapy, particularly doxorubicin, is known to cause cumulative, dose-dependent cardiomyocyte death (Volkova & Russell, 2011). In addition, many older women diagnosed with breast cancer have preexisting comorbidities, such as coronary artery disease, hypertension, and diabetes. Cardiotoxic breast cancer therapies interact synergistically with these cardiovascular risk factors to increase the risk of heart failure (Lindenfeld & Kelly, 2010; Schmitz et al., 2012).

Older adults with cancer have high rates of multimorbidity and increasing multimorbidity in the years following cancer treatment (Kenzik, Kent, Martin, Bhatia, & Pisu, 2016; Leach et al., 2015). On average, breast cancer survivors report 5.8 chronic conditions, including 2.9 conditions that occurred post–cancer diagnosis (Leach et al., 2015). In aging cancer survivors, comorbid conditions often occur in multimorbidity clusters, distinct clusters of two or more conditions. In particular, the prevalence of co-occurring hypertension and diabetes has been found to increase post–breast cancer diagnosis among older women (Kenzik et al., 2016). Additional comorbidities are most likely to occur after breast cancer diagnosis for women who are obese, physically inactive, or more than 10 years post–cancer diagnosis (Leach et al., 2015). Cancer diagnosis may also contribute to more rapid decline in physical function among older adults, particularly those with multimorbidity (Leach et al., 2016; Meneses, Benz, Azuero, Jablonski-Jaudon, & McNees, 2015). Because of the complexity of this patient population, cancer treatment decision making and prioritization of care is a challenge (Leach et al., 2015; Meneses et al., 2015).

Little is known about the association between heart failure and long-term survival among older women with breast cancer. Women with breast cancer with comorbidities, such as heart failure, are typically excluded from oncology clinical trials (Lewis et al., 2003), and clinical studies with limited follow-up time underestimate the long-term survival impact of heart failure in patients with breast cancer (Pinder et al., 2007). In addition, it is unclear how the relative contribution of heart failure to mortality risk varies by breast cancer stage—an important consideration because the competing mortality risk of heart failure must be weighed against the benefits of cancer treatment for each individual.

Therefore, the authors conducted a retrospective cohort study to examine the association between heart failure and long-term survival among older women with breast cancer. The findings have implications for breast cancer survivorship care, including the need for better integration of healthcare services for cancer survivors at risk for cardiovascular complications, particularly during the transition from oncology to primary care.

Methods

Data Source

The authors undertook a population-based approach, using data from the National Cancer Institute’s (NCI’s) Surveillance, Epidemiology, and End Results (SEER) cancer registries linked to the annual Medicare Health Outcomes Survey (MHOS) for survey years 1998–2013 (Kent et al., 2016). SEER data contain robust clinical information on cancer diagnosis, disease stage, and mortality. The MHOS is a self-administered mailed survey distributed annually to randomly selected enrollees in Medicare managed care plans (i.e., Medicare Advantage) that collects information on health status and self-reported chronic conditions. The authors used the MHOS data to identify individuals in SEER who had self-reported heart failure (yes or no). Self-reported conditions on the MHOS were shown to have acceptable sensitivity and specificity when validated against patient medical records (Miller et al., 2008).

Population

The study population included women aged 65 years or older at the time of survey completion who had a previous diagnosis of invasive breast cancer and completed the MHOS survey within five years of breast cancer diagnosis. Women who had a history of other primary cancers were excluded. Summing across 14 years of SEER-MHOS cohorts, the authors initially identified 42,335 women with breast cancer. Women with in situ tumors (stage 0) and those with missing data for either cancer stage, date of cancer diagnosis, or heart failure status were excluded. The final sample included 3,689 women with invasive breast cancer (239 with self-reported heart failure in the MHOS survey and 3,450 without heart failure) (see Figure 1).

Measures

Heart failure status: The MHOS contains the following question: Has a doctor ever told you that you had congestive heart failure? Respondents check a box to indicate “yes” or “no.” Date of heart failure diagnosis is not reported in MHOS data; therefore, the sequence of breast cancer and heart failure was unknown.

Survivorship: SEER-MHOS reports the dates of cancer diagnoses obtained from SEER registries, as well as the month and year of death obtained from the Medicare enrollment database for individuals who have died. Among women who died, survival time was calculated as the number of months from date of cancer diagnosis to date of death reported in the Medicare enrollment database. The date of last follow-up was November 30, 2014; therefore, all women who had not died by that date were censored (i.e., the study follow-up period ended before an event occurred), and survival time was calculated from the date of breast cancer diagnosis.

Covariates: The authors anticipated that women with and without heart failure would differ in regard to breast cancer variables and health status. To be used as potential covariates in the statistical models, information on cancer site, cancer stage, age at diagnosis, and month and year of diagnosis were collected from SEER data and self-reported medical conditions (e.g., hypertension, diabetes) obtained from the MHOS.

Statistical Analysis

Estimated survival was calculated using the Kaplan-Meier Estimator. The authors estimated survival for the entire cohort and by heart failure status (heart failure diagnosis reported as yes or no). Cox proportional hazards regression were then used to examine the association between heart failure status and mortality for up to 10 years after cancer diagnosis overall and by breast cancer stage. Variables in the Cox proportional hazards model included age, race and ethnicity, smoking status, use of a proxy for survey completion, cancer stage, breast tumor estrogen receptor status, diabetes, stroke, and chronic lung disease. Variables were selected based on their association with mortality risk in breast cancer survivors (Cianfrocca & Goldstein, 2004; Klabunde, Legler, Warren, Baldwin, & Schrag, 2007). Because other cardiovascular conditions are likely intermediates in the relationship between heart failure and mortality, the authors did not include such factors as covariates in the statistical models. Analyses were performed in Stata, version 14.0. Two-sided tests with alpha level of 0.05 based on complete case analysis were used for all analyses. Missing values were assumed to be missing completely at random.

Results

Participant Characteristics

Women with heart failure differed from those without heart failure in several ways (see Table 1). For example, women with heart failure were, on average, older (78 years versus 76 years) and more likely to be non-Hispanic Black compared to those without heart failure (15% versus 8%, p < 0.01). Women with heart failure were more likely to report comorbidities, including hypertension, diabetes, other cardiovascular conditions, chronic lung disease, and arthritis. The heart failure group also included a greater proportion of patients with advanced stage (III/IV) cancer than women without heart failure (16% versus 10%, p < 0.01).

Survival Outcomes by Heart Failure Status

Overall, survival rates were lower among women with heart failure compared to those without heart failure throughout follow-up (see Table 2 and Figure 2). Five-year survival rates in women with heart failure exceeded 70% for women with stage I or II cancer and were 48% for stage III/IV cancer. At 10 years after breast cancer diagnosis, survival rates in women with heart failure and stage I, II, or III/IV cancer fell to 43%, 40%, and 22%, respectively. The contrast in survivorship between participants with and without heart failure was most pronounced at 10 years postdiagnosis. Among all study participants, after adjustment for covariates, heart failure was independently and significantly associated with increased likelihood of death for up to 10 years after cancer diagnosis (adjusted hazard ratio [HR] = 1.62, 95% confidence interval [CI] [1.32, 2]). Other significant predictors of 10-year mortality, in addition to age and cancer stage, were smoking, diabetes, stroke, and chronic lung disease (range of HR = 1.23–1.87, p < 0.01 for all) (see Table 3).

In adjusted subanalyses stratified by cancer stage, heart failure was associated with increased likelihood of death in women with stage I (HR = 1.72, 95% CI [1.24, 2.38]) or II (HR = 2.06, 95% CI [1.46, 2.93]) cancer up to 10 years after cancer diagnosis but not in women with advanced stage III/IV cancer (HR = 1.27, 95% CI [0.82, 1.98]).

Discussion

Heart failure was associated with significantly lower short- and long-term survival rates among older women with early-stage cancer but less so among women with more advanced cancer. This finding may seem counterintuitive because early-stage breast cancer is generally associated with better prognosis. However, for this group, the competing mortality risk of heart failure may be greater than cancer. Clinicians should prioritize prevention and management of cardiovascular disease, particularly among women with early-stage breast cancer. As expected, women with heart failure also had greater comorbidity burden that may contribute to mortality risk. These findings have important implications for the clinical care of patients as they are diagnosed with breast cancer, as well as subsequent survivorship care.

Survival among women without heart failure was comparable to postmenopausal women with invasive breast cancer (Howlader et al., 2016). Compared with existing literature, five-year survival among older women with heart failure was longer in the SEER-MHOS breast cancer population (72% versus 54% in a community-based population) (Roger et al., 2004). The shorter survival from prior data may be related to variation in heart failure type (systolic versus diastolic) and/or heart failure stage, which were unavailable for the participants in this study.

To minimize the cardiovascular risk of cancer treatment, the European Society of Cardiology recommends thorough assessment and optimization of baseline cardiovascular risk factors in patients with cancer (Zamorano et al., 2016). Clinical guidelines vary in regard to recommended frequency of cardiac surveillance in patients with cancer. The European Society of Cardiology recommends baseline echocardiography before treatment and continued surveillance with echocardiography after every four cycles of trastuzumab or 200 mg/m2 of doxorubicin, or more frequently for patients with cardiac risk factors or abnormal baseline cardiac function (Zamorano et al., 2016). The American Society of Clinical Oncology also recommends routine surveillance with echocardiography for individuals undergoing treatment with cardiotoxic agents (e.g., anthracyclines, trastuzumab, mediastinal radiation), with the frequency of screening at the discretion of providers based on clinical judgment (Armenian et al., 2017). Prophylactic treatment with ACE (angiotensin-converting enzyme) inhibitors and beta blockers benefits patients with preexisting cardiovascular disease, but the benefit for patients with low baseline risk is unclear (Zamorano et al., 2016). Cardiovascular risk stratification may be useful to identify patients in need of more frequent screening and subsequent intervention (Ezaz, Long, Gross, & Chen, 2014; Francis, Cheng, Arteaga, & Moslehi, 2014). Patients with breast cancer with multimorbidity should continue to see their primary provider for comprehensive assessment of functional status, nutritional status, cognition, medications, and psychosocial concerns (Meneses et al., 2015).

Patients with multiple chronic illnesses face competing mortality threats. Prospective longitudinal studies can examine the trajectory of cardiovascular disease development in aging cancer survivors, particularly women, while determining the effects of preexisting comorbidities and cancer treatment variables. A greater understanding of the disease trajectories that occur after a cancer diagnosis can inform strategies for risk-adapted surveillance to prevent cardiovascular complications, as well as strategies to better manage preexisting cardiovascular disease in older adults with cancer. Leveraging population-level data to examine these outcomes in cancer survivors is a major research priority identified by the NCI (Shelburne et al., 2014). The NCI has proposed development of a national registry of cardiovascular outcomes in patients with cancer to inform cancer treatment, supportive, and survivorship care (Shelburne et al., 2014).

Given the competing mortality risk associated with heart failure in older women with early-stage breast cancer, providers need to carefully weigh the risks of cardiotoxic cancer therapies against the potential survival benefits. Aggressive, multimodal treatment of early-stage breast cancer may cause more harm than benefit, particularly for older women with increased cardiovascular risk. Many low-risk tumors detected via mammography are treated with unnecessary mastectomies that can lead to complications from surgery (Alvarado, Ozanne, & Esserman, 2012). Based on molecular profiling, women older than age 50 years are more likely to have biologically low-risk tumors that are responsive to endocrine therapy and may not require systemic chemotherapy (Esserman et al., 2011). In addition to molecular profiling of tumors, clinical decision support tools to predict risk of breast cancer recurrence based on tumor characteristics can prevent overtreatment of early-stage disease (Esserman et al., 2011).

Although guidelines have been released for management of breast cancer in older women (Biganzoli et al., 2012), a need exists for clinician education regarding treatment guidelines for patients with early-stage breast cancer with multimorbidity (Jones, Leak, & Muss, 2012). In some cases, breast cancer may not be the patient’s primary illness if she has preexisting comorbidities that decrease her life expectancy and increase the risk of treatment complications (Jones et al., 2012). Compared to younger individuals, older adults tend to emphasize quality of life over survival gains when making cancer treatment decisions (Wedding, Pientka, & Höffken, 2007). Adverse effects of breast cancer treatment can lead to cardiovascular complications, functional loss, and reduced quality of life (Ganz et al., 2002; Harrison et al., 2017; Schmitz et al., 2012). For this reason, patient–provider communication is important to help older adults make informed decisions regarding cancer treatment.

Substantial challenges exist to optimal management of patients with breast cancer and heart failure. Primary care providers have limited training in cancer survivorship issues and may be less aware of the long-term cardiac risks of anthracyclines and other cardiotoxic breast cancer treatments (Nekhlyudov, Aziz, Lerro, & Virgo, 2012). As survivors transition from oncology to primary care, communication between oncology providers and primary care providers regarding potential long-term effects of cancer treatment is important to promote early recognition and treatment of cardiovascular complications (Dossett et al., 2017; Nekhlyudov et al., 2012). Survivorship care planning may facilitate communication between primary care and oncology specialties (Dossett et al., 2017). Traditional survivorship care plans may also be expanded to develop risk-adapted pathways for supportive care based on individual needs (Daudt et al., 2014).

Innovative models of care may promote better integration of healthcare services for patients with cancer and survivors with multimorbidity. The patient-centered medical home, a team-based model of primary care delivery, has shown potential for reducing hospital admissions and improving survival among patients with complex chronic conditions, including cancer (Sweeney, Halpert, & Waranoff, 2007). Proposed models of care for cancer survivors include a “shared care” model to promote collaboration between primary care providers and specialists, a nurse-led model of survivorship care, and specialized survivorship clinics to provide integrated health care. It is unclear which of these models is feasible, efficacious, and acceptable to patients and providers (Institute of Medicine, 2006). Large-scale health policy analyses can examine the effectiveness of different health service delivery models for cancer survivorship outcomes.

Limitations

The sample was limited to women aged 65 years or older enrolled in Medicare Advantage plans, which affects the generalizability of the results. Second, heart failure and other comorbid conditions were self-reported on the MHOS, and temporality of heart failure diagnosis in relation to breast cancer diagnosis was unknown. However, heart failure and other self-reported conditions on the MHOS have been shown to have acceptable sensitivity and specificity (Miller et al., 2008). Third, clinical data regarding heart failure type and stage and details of chemotherapy regimens and hormonal therapies were unavailable. The results are biased toward the null because some women without heart failure had other self-reported heart conditions; however, the authors chose not to exclude these individuals to obtain a representative sample of older women with breast cancer. Participants may have had additional unreported comorbidities. Finally, social determinants of health, such as socioeconomic status, access to care, and physical environment, are major drivers of health disparities in cardiovascular disease outcomes, including racial and geographic disparities (Davis, Gebreab, Quarells, & Gibbons, 2014; Havranek et al., 2015). Future prospective studies should evaluate social determinants that may affect cardiovascular outcomes in cancer survivors. Despite these limitations, strengths of this study included a large national dataset with a representative sample of the U.S. population and detailed cancer data.

Implications for Nursing

Multimorbidity in older adults with cancer complicates coordination of cancer treatment and primary care. In addition to thorough evaluation and treatment of existing comorbidities at the time of breast cancer diagnosis, patients with comorbidity may benefit from routine follow-up with a primary care provider for medical management of existing health issues and comprehensive assessment of health and functional status (Meneses et al., 2015). Survivorship care planning can improve care coordination for cancer survivors at risk for cardiovascular complications, particularly during the transition from oncology to primary care. The majority of survivorship care plans are delivered by oncology nurses or nurse practitioners during clinic visits (Daudt et al., 2014). Care plans should summarize the patient’s cancer treatment history, including potential late effects of cancer treatment, preventive measures to maintain long-term health, and the timing and specific details of recommended follow-up care (Institute of Medicine, 2006). Nurse-led survivorship care–planning initiatives can help to ensure that older adults receive follow-up care consistent with evidence-based guidelines (Lester, Wessels, & Jung, 2014). In particular, guideline-recommended cardiac surveillance to promote early identification and treatment of left ventricular dysfunction is important to prevent development of chronic heart failure (Armenian et al., 2017; Zamorano et al., 2016). The expansion of traditional survivorship care planning to encompass the entire trajectory from cancer diagnosis through survivorship may improve the patient experience while preventing treatment complications (Daudt et al., 2014). Risk-adapted pathways that address individual risk factors and comorbidities may be useful to guide supportive care from the time of cancer diagnosis through survivorship (Daudt et al., 2014).

To improve outcomes for this vulnerable population, nurses caring for patients with invasive breast cancer should assess for risk factors that predispose women to cardiotoxic heart failure, including advanced age, obesity, comorbidity, and lifestyle factors, such as smoking (Lindenfeld & Kelly, 2010; Schmitz et al., 2012). Clinicians need to educate women treated for breast cancer and their family members about the need for continued follow-up care to evaluate cardiac function, as well as the importance of addressing cardiovascular risk factors, such as tobacco use, hypertension, and hypercholesterolemia (Mozaffarian et al., 2016). Women at higher risk would benefit from educational interventions and continued evaluation for new symptoms. In planning care for these patients, nurses should consider obtaining referrals for cardiology or cardio-oncology clinics for requisite diagnostic testing. In addition, patients should be able to identify signs and symptoms, such as dyspnea and fatigue, that should alert them to contact their provider for further assessment. Symptoms such as fatigue in women with subclinical cardiovascular disease may be mistaken for lingering cancer-related symptoms (Schünemann, Anker, & Rauchhaus, 2008). Should a diagnosis of cardiotoxic heart failure be made, ongoing assessment and monitoring for functional deficits should warrant referrals to physical and occupational therapy. In the literature review, the authors found no evidence-based nursing interventions for women at risk for cardiotoxic heart failure following a diagnosis of invasive breast cancer. The intervention with the highest level of evidence but lowest uptake in this population is moderate exercise to ameliorate lingering fatigue and activity intolerance (Mason et al., 2013; McNeely et al., 2006; Schmitz et al., 2010). Given the rising prevalence and symptom burdens, this patient population has a growing need for intervention development and evaluation.

Conclusion

The authors found that heart failure is associated with significantly worse prognosis for older women with early-stage breast cancer. Prevention and management of cardiovascular comorbidities and other chronic conditions in this population should remain a priority after cancer diagnosis. Prospective research can inform strategies for supportive care coordination and risk-adapted cardiac surveillance in breast cancer survivors, and development of innovative healthcare delivery models can improve patient outcomes among the growing population of older adults with cancer and cardiovascular comorbidity.

About the Author(s)

Jordan M. Harrison, PhD, RN, is a research fellow in the Center for Health Outcomes and Policy Research in the School of Nursing and a national clinician scholar in the Perelman School of Medicine at the University of Pennsylvania in Philadelphia; Christopher R. Friese, PhD, RN, AOCN®, FAAN, is the Elizabeth Tone Hosmer professor of nursing and Debra L. Barton, PhD, RN, AOCN®, FAAN, is the Mary Lou Willard endowed professor of oncology nursing, both in the School of Nursing, and Nancy K. Janz, PhD, is a professor in the School of Public Health, all at the University of Michigan in Ann Arbor; Susan J. Pressler, PhD, RN, FAAN, FAHA, is a professor, the Sally Reahard endowed chair, and the director of the Center for Enhancing Quality of Life in Chronic Illness in the School of Nursing at Indiana University in Indianapolis; and Matthew A. Davis, PhD, MPH, is an assistant professor in the School of Nursing at the University of Michigan. This research was funded by the Rackham Graduate School at the University of Michigan through support from the University of Michigan Hillman Scholars Program. Harrison, Friese, and Davis provided statistical support and the analysis. Harrison and Friese completed the data collection. All authors contributed to the conceptualization and design and manuscript preparation. Harrison can be reached at joharr@nursing.upenn.edu, with copy to ONFEditor@ons.org. (Submitted May 2017. Accepted July 12, 2017.)

 

References 

Alvarado, M., Ozanne, E., & Esserman, L. (2012). Overdiagnosis and overtreatment of breast cancer. American Society of Clinical Oncology Educational Book, 2012, e40–e45. https://doi.org/10.14694/EdBook_AM.2012.32.e40

Armenian, S.H.., Lacchetti, C., Barac, A., Carver, J., Constine, L.S., Denduluri, N., . . . Lenihan, D. (2017). Prevention and monitoring of cardiac dysfunction in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline. Journal of Clinical Oncology, 35, 893–911. https://doi.org/10.1200/JCO.2016.70.5400

Biganzoli, L., Wildiers, H., Oakman, C., Marotti, L., Loibl, S., Kunkler, I., . . . Audisio, R. (2012). Management of elderly patients with breast cancer: Updated recommendations of the International Society of Geriatric Oncology (SIOG) and European Society of Breast Cancer Specialists (EUSOMA). Lancet Oncology, 13(4), e148–e160. https://doi.org/10.1016/S1470-2045(11)70383-7

Cianfrocca, M., & Goldstein, L.J. (2004). Prognostic and predictive factors in early-stage breast cancer. Oncologist, 9, 606–616. https://doi.org/10.1634/theoncologist.9-6-606

Daudt, H.M., van Mossel, C., Dennis, D.L., Leitz, L., Watson, H.C., & Tanliao, J.J. (2014). Survivorship care plans: A work in progress. Current Oncology, 21(3), e466–e479. https://doi.org/10.3747/co.21.1781

Davis, S.K., Gebreab, S., Quarells, R., & Gibbons, G.H. (2014). Social determinants of cardiovascular health among black and white women residing in Stroke Belt and Buckle regions of the South. Ethnicity and Disease, 24, 133–143.

Dossett, L.A., Hudson, J.N., Morris, A.M., Lee, M.C., Roetzheim, R.G., Fetters, M.D., & Quinn, G.P. (2017). The primary care provider (PCP)-cancer specialist relationship: A systematic review and mixed-methods meta-synthesis. CA: A Cancer Journal for Clinicians, 67, 156–169. https://doi.org/10.3322/caac.21385

Esserman, L.J., Shieh, Y., Rutgers, E.J., Knauer, M., Retèl, V.P., Mook, S., . . . Van ’t Veer, L.J. (2011). Impact of mammographic screening on the detection of good and poor prognosis breast cancers. Breast Cancer Research and Treatment, 130, 725–734. https://doi.org/10.1007/s10549-011-1748-z

Ezaz, G., Long, J.B., Gross, C.P., & Chen, J. (2014). Risk prediction model for heart failure and cardiomyopathy after adjuvant trastuzumab therapy for breast cancer. Journal of the American Heart Association, 3(1), e000472. https://doi.org/10.1161/JAHA.113.000472

Francis, S.A., Cheng, S., Arteaga, C.L., & Moslehi, J. (2014). Heart failure and breast cancer therapies: Moving towards personalized risk assessment. Journal of the American Heart Association, 3(1), e000780. https://doi.org/10.1161/JAHA.113.000780

Ganz, P.A., Desmond, K.A., Leedham, B., Rowland, J.H., Meyerowitz, B.E., & Belin, T.R. (2002). Quality of life in long-term, disease-free survivors of breast cancer: A follow-up study. Journal of the National Cancer Institute, 94, 39–49. https://doi.org/10.1093/jnci/94.1.39

Harrison, J.M., Davis, M.A., Barton, D.L., Janz, N.K., Pressler, S.J., & Friese, C.R. (2017). Functional status and quality of life among breast cancer survivors with heart failure: Results of the Medicare Health Outcomes Survey. Supportive Care in Cancer, 25, 2453–2473. https://doi.org/10.1007/s00520-017-3653-4

Havranek, E.P., Mujahid, M.S., Barr, D.A., Blair, I.V., Cohen, M.S., Cruz-Flores, S., . . . Yancy, C.W. (2015). Social determinants of risk and outcomes for cardiovascular disease: A scientific statement from the American Heart Association. Circulation, 132, 873–898. https://doi.org/10.1161/CIR.0000000000000228

Howlader, N., Noone, A., Krapcho, M., Miller, D., Bishop, K., Altekruse, S.F., . . . Cronin, K.A. (Eds.). (2016). SEER cancer statistics review, 1975–2013. Bethesda, MD: National Cancer Institute. Retrieved from https://seer.cancer.gov/csr/1975_2013/

Hung, W.W., Ross, J.S., Boockvar, K.S., & Siu, A.L. (2011). Recent trends in chronic disease, impairment and disability among older adults in the United States. BMC Geriatrics, 11, 47. https://doi.org/10.1186/1471-2318-11-47

Hung, W.W., Ross, J.S., Boockvar, K.S., & Siu, A.L. (2012). Association of chronic diseases and impairments with disability in older adults: A decade of change? Medical Care, 50, 501–507. https://doi.org/10.1097/MLR.0b013e318245a0e0

Institute of Medicine. (2006). From cancer patient to cancer survivor: Lost in translation. Washington, DC: National Academies Press.

Jones, E.L., Leak, A., & Muss, H.B. (2012). Adjuvant therapy of breast cancer in women 70 years of age and older: Tough decisions, high stakes. Oncology (Williston Park), 26, 793–801.

Kent, E.E., Malinoff, R., Rozjabek, H.M., Ambs, A., Clauser, S.B., Topor, M.A., . . . DeMichele, K. (2016). Revisiting the surveillance epidemiology and end results cancer registry and medicare health outcomes survey (SEER-MHOS) linked data resource for patient-reported outcomes research in older adults with cancer. Journal of the American Geriatrics Society, 64, 186–192. https://doi.org/10.1111/jgs.13888

Kenzik, K.M., Kent, E.E., Martin, M.Y., Bhatia, S., & Pisu, M. (2016). Chronic condition clusters and functional impairment in older cancer survivors: A population-based study. Journal of Cancer Survivorship, 10, 1096–1103. https://doi.org/10.1007/s11764-016-0553-4

Klabunde, C.N., Legler, J.M., Warren, J.L., Baldwin, L.M., & Schrag, D. (2007). A refined comorbidity measurement algorithm for claims-based studies of breast, prostate, colorectal, and lung cancer patients. Annals of Epidemiology, 17, 584–590. https://doi.org/10.1016/j.annepidem.2007.03.011

Leach, C.R., Bellizzi, K.M., Hurria, A., & Reeve, B.B. (2016). Is it my cancer or am I just getting older?: Impact of cancer on age-related health conditions of older cancer survivors. Cancer, 122, 1946–1953. https://doi.org/10.1002/cncr.29914

Leach, C.R., Weaver, K.E., Aziz, N.M., Alfano, C.M., Bellizzi, K.M., Kent, E.E., . . . Rowland, J.H. (2015). The complex health profile of long-term cancer survivors: Prevalence and predictors of comorbid conditions. Journal of Cancer Survivorship, 9, 239–251. https://doi.org/10.1007/s11764-014-0403-1

Lester, J.L., Wessels, A.L., & Jung, Y. (2014). Oncology nurses’ knowledge of survivorship care planning: The need for education [Online exclusive]. Oncology Nursing Forum, 41, E35–E43. https://doi.org/10.1188/14.ONF.E35-E43

Lewis, J.H., Kilgore, M.L., Goldman, D.P., Trimble, E.L., Kaplan, R., Montello, M.J., . . . Escarce, J.J. (2003). Participation of patients 65 years of age or older in cancer clinical trials. Journal of Clinical Oncology, 21, 1383–1389. https://doi.org/10.1200/JCO.2003.08.010

Lindenfeld, J., & Kelly, P.A. (2010). Developing a cardiology-oncology clinical practice guideline. Progress in Cardiovascular Diseases, 53, 173–179. https://doi.org/10.1016/j.pcad.2010.06.001

Mason, C., Alfano, C.M., Smith, A.W., Wang, C.Y., Neuhouser, M.L., Duggan, C., . . . McTiernan, A. (2013). Long-term physical activity trends in breast cancer survivors. Cancer Epidemiology, Biomarkers and Prevention, 22, 1153–1161. https://doi.org/10.1158/1055-9965.EPI-13-0141

McNeely, M.L., Campbell, K.L., Rowe, B.H., Klassen, T.P., Mackey, J.R., & Courneya, K.S. (2006). Effects of exercise on breast cancer patients and survivors: A systematic review and meta-analysis. Canadian Medical Association Journal, 175, 34–41. https://doi.org/10.1503/cmaj.051073

Meneses, K., Benz, R., Azuero, A., Jablonski-Jaudon, R., & McNees, P. (2015). Multimorbidity and breast cancer. Seminars in Oncology Nursing, 31, 163–169. https://doi.org/10.1016/j.soncn.2015.02.004

Miller, D.R., Rogers, W.H., Kazis, L.E., Spiro, A., 3rd., Ren, X.S., & Haffer, S.C. (2008). Patients’ self-report of diseases in the Medicare Health Outcomes Survey based on comparisons with linked survey and medical data from the Veterans Health Administration. Journal of Ambulatory Care Management, 31, 161–177. https://doi.org/10.1097/01.JAC.0000314707.88160.9c

Moslehi, J. (2013). The cardiovascular perils of cancer survivorship. New England Journal of Medicine, 368, 1055–1056. https://doi.org/10.1056/NEJMe1215300

Moslehi, J.J. (2016). Cardiovascular toxic effects of targeted cancer therapies. New England Journal of Medicine, 375, 1457–1467. https://doi.org/10.1056/NEJMra1100265

Mozaffarian, D., Benjamin, E.J., Go, A.S., Arnett, D.K., Blaha, M.J., Cushman, M., . . . Turner, M.B. (2016). Heart disease and stroke statistics—2016 update: A report from the American Heart Association. Circulation, 133(4), e38–e360. https://doi.org/10.1161/CIR.0000000000000350

Nekhlyudov, L., Aziz, N., Lerro, C.C., & Virgo, K.S. (2012). Oncologists’ and primary care providers’ awareness of late effects of cancer treatment: Implications for survivorship care [Abstract 6008]. Journal of Clinical Oncology, 30(Suppl. 15), 6008. https://doi.org/10.1200/jco.2012.30.15_suppl.6008

Patnaik, J.L., Byers, T., Diguiseppi, C., Denberg, T.D., & Dabelea, D. (2011). The influence of comorbidities on overall survival among older women diagnosed with breast cancer. Journal of the National Cancer Institute, 103, 1101–1111. https://doi.org/10.1093/jnci/djr188

Pinder, M.C., Duan, Z., Goodwin, J.S., Hortobagyi, G.N., & Giordano, S.H. (2007). Congestive heart failure in older women treated with adjuvant anthracycline chemotherapy for breast cancer. Journal of Clinical Oncology, 25, 3808–3815. https://doi.org/10.1200/JCO.2006.10.4976

Roger, V.L., Weston, S.A., Redfield, M.M., Hellermann-Homan, J.P., Killian, J., Yawn, B.P., & Jacobsen, S.J. (2004). Trends in heart failure incidence and survival in a community-based population. JAMA, 292, 344–350. https://doi.org/10.1001/jama.292.3.344

Schmitz, K.H., Courneya, K.S., Matthews, C., Demark-Wahnefried, W., Galvão, D.A., Pinto, B.M., . . . Schwartz, A.L. (2010). American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Medicine and Science in Sports and Exercise, 42, 1409–1426. http://doi.org/10.1249/MSS.0b013e3181e0c112

Schmitz, K.H., Prosnitz, R.G., Schwartz, A.L., & Carver, J.R. (2012). Prospective surveillance and management of cardiac toxicity and health in breast cancer survivors. Cancer, 118(Suppl. 8), 2270–2276. https://doi.org/10.1002/cncr.27462

Schünemann, M., Anker, S.D., & Rauchhaus, M. (2008). Cancer fatigue syndrome reflects clinically non-overt heart failure: An approach towards oncocardiology. Nature Clinical Practice Oncology, 5, 632–633. https://doi.org/10.1038/ncponc1226

Shelburne, N., Adhikari, B., Brell, J., Davis, M., Desvigne-Nickens, P., Freedman, A., . . . Remick, S.C. (2014). Cancer treatment–related cardiotoxicity: Current state of knowledge and future research priorities. Journal of the National Cancer Institute, 106(9), pii: dju232. https://doi.org/10.1093/jnci/dju232

Smith, B.D., Smith, G.L., Hurria, A., Hortobagyi, G.N., & Buchholz, T.A. (2009). Future of cancer incidence in the United States: Burdens upon an aging, changing nation. Journal of Clinical Oncology, 27, 2758–2765. https://doi.org/10.1200/JCO.2008.20.8983

Sweeney, L., Halpert, A., & Waranoff, J. (2007). Patient-centered management of complex patients can reduce costs without shortening life. American Journal of Managed Care, 13(2), 84–92.

Volkova, M., & Russell, R. (2011). Anthracycline cardiotoxicity: Prevalence, pathogenesis and treatment. Current Cardiology Reviews, 7, 214–220. https://doi.org/10.2174/157340311799960645

Wedding, U., Pientka, L., & Höffken, K. (2007). Quality-of-life in elderly patients with cancer: A short review. European Journal of Cancer, 43, 2203–2210. https://doi.org/10.1016/j.ejca.2007.06.001

Zamorano, J.L., Lancellotti, P., Rodriguez Muñoz, D., Aboyans, V., Asteggiano, R., Galderisi, M., . . . Suter, T.M. (2016). 2016 ESC position paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines: The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC). European Heart Journal, 37, 2768–2801. https://doi.org/10.1093/eurheartj/ehw211