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ONS Guidelines Article
Online Exclusive Article

Comparing Interventions for Management of Hot Flashes in Patients With Breast and Prostate Cancer: A Systematic Review With Meta-Analyses

Brian Hutton
Mona Hersi
Wei Cheng
Misty Pratt
Pauline Barbeau
Sasha Mazzarello
Nadera Ahmadzai
Becky Skidmore
Scott C. Morgan
Louise Bordeleau
Pamela K. Ginex
Behnam Sadeghirad
Rebecca L. Morgan
Katherine Marie Cole
Mark Clemons
ONF 2020, 47(4), E86-E106 DOI: 10.1188/20.ONF.E86-E106

Problem Identification: Hot flashes are common and bothersome in patients with breast and prostate cancer and can adversely affect patients’ quality of life.

Literature Search: Databases were searched for randomized controlled trials (RCTs) evaluating the effects of one or more interventions for hot flashes in patients with a history of breast or prostate cancer.

Data Evaluation: Outcomes of interest included changes in hot flash severity, hot flash frequency, quality of life, and harms. Pairwise meta-analyses and network meta-analyses were performed where feasible, with narrative synthesis used where required.

Synthesis: 40 RCTs were included. Findings from network meta-analysis for hot flash frequency suggested that several therapies may offer benefits compared to no treatment, but little data suggested differences between active therapies. Findings from network meta-analysis for hot flash score were similar.

Implications for Research: Although many interventions may offer improvements for hot flashes versus no treatment, minimal data suggest important differences between therapies.

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